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EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Morel KL, Sheahan AV, Burkhart DL, Baca SC, Boufaied N, Liu Y, Qiu X, Cañadas I, Roehle K, Heckler M, Calagua C, Ye H, Pantelidou C, Galbo P, Panja S, Mitrofanova A, Wilkinson S, Whitlock NC, Trostel SY, Hamid AA, Kibel AS, Barbie DA, Choudhury AD, Pomerantz MM, Sweeney CJ, Long HW, Einstein DJ, Shapiro GI, Dougan SK, Sowalsky AG, He HH, Freedman ML, Balk SP, Loda M, Labbé DP, Olson BM, Ellis L. Morel KL, et al. Among authors: dougan sk. Nat Cancer. 2021 Apr;2(4):444-456. doi: 10.1038/s43018-021-00185-w. Epub 2021 Mar 22. Nat Cancer. 2021. PMID: 33899001 Free PMC article.
In vivo discovery of immunotherapy targets in the tumour microenvironment.
Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. Zhou P, et al. Among authors: dougan sk. Nature. 2014 Feb 6;506(7486):52-7. doi: 10.1038/nature12988. Epub 2014 Jan 29. Nature. 2014. PMID: 24476824 Free PMC article.
TGFβ: Protecting PD-1 from mRNA Decay.
Dougan SK. Dougan SK. Cancer Immunol Res. 2020 Dec;8(12):1464. doi: 10.1158/2326-6066.CIR-20-0881. Cancer Immunol Res. 2020. PMID: 33262162
Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation.
Heckler M, Ali LR, Clancy-Thompson E, Qiang L, Ventre KS, Lenehan P, Roehle K, Luoma A, Boelaars K, Peters V, McCreary J, Boschert T, Wang ES, Suo S, Marangoni F, Mempel TR, Long HW, Wucherpfennig KW, Dougan M, Gray NS, Yuan GC, Goel S, Tolaney SM, Dougan SK. Heckler M, et al. Among authors: dougan sk, dougan m. Cancer Discov. 2021 Oct;11(10):2564-2581. doi: 10.1158/2159-8290.CD-20-1540. Epub 2021 May 3. Cancer Discov. 2021. PMID: 33941591 Free PMC article.
cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes.
Roehle K, Qiang L, Ventre KS, Heid D, Ali LR, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM, Yang A, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M, Wucherpfennig KW, Stanger BZ, Akin JJ, Mancias JD, Agudo J, Dougan M, Dougan SK. Roehle K, et al. Among authors: dougan sk, dougan m. Sci Transl Med. 2021 May 19;13(594):eabf5058. doi: 10.1126/scitranslmed.abf5058. Sci Transl Med. 2021. PMID: 34011631 Free PMC article.
Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma.
Cleary JM, Wolpin BM, Dougan SK, Raghavan S, Singh H, Huffman B, Sethi NS, Nowak JA, Shapiro GI, Aguirre AJ, D'Andrea AD. Cleary JM, et al. Among authors: dougan sk. Clin Cancer Res. 2021 Dec 15;27(24):6622-6637. doi: 10.1158/1078-0432.CCR-21-1367. Epub 2021 Jul 20. Clin Cancer Res. 2021. PMID: 34285063 Free PMC article. Review.
Type 2 immunity is maintained during cancer-associated adipose tissue wasting.
Lenehan PJ, Cirella A, Uchida AM, Crowley SJ, Sharova T, Boland G, Dougan M, Dougan SK, Heckler M. Lenehan PJ, et al. Among authors: dougan sk, dougan m. Immunother Adv. 2021 Jun 2;1(1):ltab011. doi: 10.1093/immadv/ltab011. eCollection 2021 Jan. Immunother Adv. 2021. PMID: 34291232 Free PMC article.
Dangerous dynamic duo: Lactic acid and PD-1 blockade.
Johnson S, Haigis MC, Dougan SK. Johnson S, et al. Among authors: dougan sk. Cancer Cell. 2022 Feb 14;40(2):127-130. doi: 10.1016/j.ccell.2022.01.008. Epub 2022 Jan 28. Cancer Cell. 2022. PMID: 35093211 Free article.
99 results