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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.
Hartman G, Humphries P, Hughes R, Ho A, Montgomery R, Deshpande A, Mahanta M, Tronnes S, Cowdin S, He X, Liu F, Zhang L, Liu C, Dou D, Li J, Spasic A, Coll R, Marleaux M, Hochheiser IV, Geyer M, Rubin P, Fortney K, Wilhelmsen K. Hartman G, et al. Among authors: dou d. Bioorg Med Chem Lett. 2024 Apr 1;102:129675. doi: 10.1016/j.bmcl.2024.129675. Epub 2024 Feb 28. Bioorg Med Chem Lett. 2024. PMID: 38417632
Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach.
Chen Q, Liu C, Wang W, Meng X, Cheng X, Li X, Cai L, Luo L, He X, Qu H, Luo J, Wei H, Gao S, Liu G, Wan J, Israel DI, Li J, Dou D. Chen Q, et al. Among authors: dou d. ACS Chem Biol. 2023 Jan 20;18(1):25-33. doi: 10.1021/acschembio.2c00797. Epub 2023 Jan 6. ACS Chem Biol. 2023. PMID: 36606710 Free PMC article.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Kung PP, Bingham P, Burke BJ, Chen Q, Cheng X, Deng YL, Dou D, Feng J, Gallego GM, Gehring MR, Grant SK, Greasley S, Harris AR, Maegley KA, Meier J, Meng X, Montano JL, Morgan BA, Naughton BS, Palde PB, Paul TA, Richardson P, Sakata S, Shaginian A, Sonnenburg WK, Subramanyam C, Timofeevski S, Wan J, Yan W, Stewart AE. Kung PP, et al. Among authors: dou d. ACS Med Chem Lett. 2020 Apr 10;11(6):1175-1184. doi: 10.1021/acsmedchemlett.0c00029. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32550998 Free PMC article.
Potent norovirus inhibitors based on the acyclic sulfamide scaffold.
Dou D, Tiew KC, Mandadapu SR, Gunnam MR, Alliston KR, Kim Y, Chang KO, Groutas WC. Dou D, et al. Bioorg Med Chem. 2012 Mar 15;20(6):2111-8. doi: 10.1016/j.bmc.2012.01.030. Epub 2012 Feb 2. Bioorg Med Chem. 2012. PMID: 22356738 Free PMC article.
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.
Lai H, Dou D, Aravapalli S, Teramoto T, Lushington GH, Mwania TM, Alliston KR, Eichhorn DM, Padmanabhan R, Groutas WC. Lai H, et al. Among authors: dou d. Bioorg Med Chem. 2013 Jan 1;21(1):102-13. doi: 10.1016/j.bmc.2012.10.058. Epub 2012 Nov 15. Bioorg Med Chem. 2013. PMID: 23211969 Free PMC article.
557 results