Dou D - Search Results

1

Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK).

Dou D, Diao Y, Sha W, Su R, Tong L, Li W, Leng L, Xie L, Yu Z, Song H, Shen Z, Zhu L, Zhao Z, Xie H, Chen Z, Li H, Xu Y. Dou D, et al. J Med Chem. 2022 Feb 10;65(3):2694-2709. doi: 10.1021/acs.jmedchem.1c02208. Epub 2022 Jan 31. J Med Chem. 2022. PMID: 35099969

2

Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors.

Diao Y, Fang X, Song P, Lai M, Tong L, Hao Y, Dou D, Liu Y, Ding J, Zhao Z, Xie H, Li H. Diao Y, et al. Among authors: dou d. Bioorg Med Chem. 2019 Aug 1;27(15):3390-3395. doi: 10.1016/j.bmc.2019.06.023. Epub 2019 Jun 12. Bioorg Med Chem. 2019. PMID: 31221612

3

Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors.

Lai MZ, Song PR, Dou D, Diao YY, Tong LJ, Zhang T, Xie H, Li HL, Ding J. Lai MZ, et al. Among authors: dou d. Acta Pharmacol Sin. 2020 Mar;41(3):415-422. doi: 10.1038/s41401-019-0250-8. Epub 2019 Jul 17. Acta Pharmacol Sin. 2020. PMID: 31316181 Free PMC article.

4

Discovery of pyrido[3,4-b]indol-1-one derivatives as novel non-covalent Bruton's tyrosine kinase (BTK) inhibitors.

Dou D, Sha W, Diao Y, Su R, Qiao Y, Yu Z, Zhao Z, Li H, Chen Z, Xu Y. Dou D, et al. Bioorg Chem. 2022 Feb;119:105541. doi: 10.1016/j.bioorg.2021.105541. Epub 2021 Dec 7. Bioorg Chem. 2022. PMID: 34910982

5

Discovery of pyrrolo[1,2-a]quinoxalin-4(5H)-one derivatives as novel non-covalent Bruton's tyrosine kinase (BTK) inhibitors.

Su R, Diao Y, Sha W, Dou D, Yu Z, Leng L, Zhao Z, Chen Z, Li H, Xu Y. Su R, et al. Among authors: dou d. Bioorg Chem. 2022 Sep;126:105860. doi: 10.1016/j.bioorg.2022.105860. Epub 2022 May 16. Bioorg Chem. 2022. PMID: 35661525

6

Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors.

Chen H, Song P, Diao Y, Hao Y, Dou D, Wang W, Fang X, Wang Y, Zhao Z, Ding J, Li H, Xie H, Xu Y. Chen H, et al. Among authors: dou d. Medchemcomm. 2018 Mar 13;9(4):697-704. doi: 10.1039/c8md00019k. eCollection 2018 Apr 1. Medchemcomm. 2018. PMID: 30108960 Free PMC article.

7

Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1.

Zhang DJ, Chen LH, Zhang YH, Yang GR, Dou D, Gao YS, Zhang XY, Kong XM, Zhao P, Pu D, Wei MF, Breyer MD, Guan YF. Zhang DJ, et al. Among authors: dou d. Acta Pharmacol Sin. 2010 Oct;31(10):1284-92. doi: 10.1038/aps.2010.99. Epub 2010 Sep 27. Acta Pharmacol Sin. 2010. PMID: 20871624 Free PMC article.

8

Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries.

An YM, Feng H, Zhang XZ, Cong X, Zhao Q, Wu LL, Dou D. An YM, et al. Among authors: dou d. Biochem Biophys Res Commun. 2017 Apr 22;486(1):178-183. doi: 10.1016/j.bbrc.2017.03.022. Epub 2017 Mar 9. Biochem Biophys Res Commun. 2017. PMID: 28285136

9

Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor response via decreasing arterial contractility.

Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian X, Yang G, Pu D, Zhang X, Kang J, Gao Y, Wang S, Breyer MD, Wang N, Zhu Y, Huang Y, Breyer RM, Guan Y. Chen L, et al. Among authors: dou d. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):3024-32. doi: 10.1161/ATVBAHA.112.254052. Epub 2012 Oct 11. Arterioscler Thromb Vasc Biol. 2012. PMID: 23065824 Free PMC article.

10

Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.

Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD. Guan Y, et al. Among authors: dou d. J Clin Invest. 2007 Sep;117(9):2496-505. doi: 10.1172/JCI29838. J Clin Invest. 2007. PMID: 17710229 Free PMC article.

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