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Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease.
Meier AB, Zawada D, De Angelis MT, Martens LD, Santamaria G, Zengerle S, Nowak-Imialek M, Kornherr J, Zhang F, Tian Q, Wolf CM, Kupatt C, Sahara M, Lipp P, Theis FJ, Gagneur J, Goedel A, Laugwitz KL, Dorn T, Moretti A. Meier AB, et al. Among authors: dorn t. Nat Biotechnol. 2023 Dec;41(12):1787-1800. doi: 10.1038/s41587-023-01718-7. Epub 2023 Apr 3. Nat Biotechnol. 2023. PMID: 37012447 Free PMC article.
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL. Moretti A, et al. Among authors: dorn t. N Engl J Med. 2010 Oct 7;363(15):1397-409. doi: 10.1056/NEJMoa0908679. Epub 2010 Jul 21. N Engl J Med. 2010. PMID: 20660394 Free article.
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.
Jung CB, Moretti A, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P, Laugwitz KL. Jung CB, et al. Among authors: dorn t. EMBO Mol Med. 2012 Mar;4(3):180-91. doi: 10.1002/emmm.201100194. Epub 2012 Jan 25. EMBO Mol Med. 2012. PMID: 22174035 Free PMC article.
Modeling long-QT syndromes with iPS cells.
Sinnecker D, Goedel A, Dorn T, Dirschinger RJ, Moretti A, Laugwitz KL. Sinnecker D, et al. Among authors: dorn t. J Cardiovasc Transl Res. 2013 Feb;6(1):31-6. doi: 10.1007/s12265-012-9416-1. Epub 2012 Oct 18. J Cardiovasc Transl Res. 2013. PMID: 23076501 Review.
Pluripotent stem cell models of human heart disease.
Moretti A, Laugwitz KL, Dorn T, Sinnecker D, Mummery C. Moretti A, et al. Among authors: dorn t. Cold Spring Harb Perspect Med. 2013 Nov 1;3(11):a014027. doi: 10.1101/cshperspect.a014027. Cold Spring Harb Perspect Med. 2013. PMID: 24186488 Free PMC article. Review.
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D. Chen Z, et al. Among authors: dorn t. Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. Eur Heart J. 2017. PMID: 28182242 Free PMC article.
Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A. Dorn T, et al. EMBO J. 2018 Jun 15;37(12):e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15. EMBO J. 2018. PMID: 29764980 Free PMC article.
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C. Moretti A, et al. Among authors: dorn t. Nat Med. 2020 Feb;26(2):207-214. doi: 10.1038/s41591-019-0738-2. Epub 2020 Jan 27. Nat Med. 2020. PMID: 31988462 Free PMC article.
128 results