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Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs).
Malecova B, Burke RS, Cochran M, Hood MD, Johns R, Kovach PR, Doppalapudi VR, Erdogan G, Arias JD, Darimont B, Miller CD, Huang H, Geall A, Younis HS, Levin AA. Malecova B, et al. Among authors: doppalapudi vr. Nucleic Acids Res. 2023 Jul 7;51(12):5901-5910. doi: 10.1093/nar/gkad415. Nucleic Acids Res. 2023. PMID: 37224533 Free PMC article.
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
Leverett CA, Sukuru SC, Vetelino BC, Musto S, Parris K, Pandit J, Loganzo F, Varghese AH, Bai G, Liu B, Liu D, Hudson S, Doppalapudi VR, Stock J, O'Donnell CJ, Subramanyam C. Leverett CA, et al. Among authors: doppalapudi vr. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. doi: 10.1021/acsmedchemlett.6b00274. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882198 Free PMC article.
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.
Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, Hudson S, Doppalapudi VR, Stock J, Tchistiakova L, Bessire AJ, Clark T, Lucas J, Hosselet C, O'Donnell CJ, Subramanyam C. Tumey LN, et al. Among authors: doppalapudi vr. ACS Med Chem Lett. 2016 Jun 22;7(11):977-982. doi: 10.1021/acsmedchemlett.6b00195. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882194 Free PMC article.
Antitumor efficacy of a thrombospondin 1 mimetic CovX-body.
Li L, Leedom TA, Do J, Huang H, Lai J, Johnson K, Osothprarop TF, Rizzo JD, Doppalapudi VR, Bradshaw CW, Lappe RW, Woodnutt G, Levin NJ, Pirie-Shepherd SR. Li L, et al. Among authors: doppalapudi vr. Transl Oncol. 2011 Aug;4(4):249-57. doi: 10.1593/tlo.11136. Epub 2011 Aug 1. Transl Oncol. 2011. PMID: 21804921 Free PMC article.
Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.
Bower KE, Lam SN, Oates BD, Del Rosario JR, Corner E, Osothprarop TF, Kinhikar AG, Hoye JA, Preston RR, Murphy RE, Campbell LA, Huang H, Jimenez J, Cao X, Chen G, Ainekulu ZW, Datt AB, Levin NJ, Doppalapudi VR, Pirie-Shepherd SR, Bradshaw C, Woodnutt G, Lappe RW. Bower KE, et al. Among authors: doppalapudi vr. J Med Chem. 2011 Mar 10;54(5):1256-65. doi: 10.1021/jm101226k. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280651
Chemical generation of bispecific antibodies.
Doppalapudi VR, Huang J, Liu D, Jin P, Liu B, Li L, Desharnais J, Hagen C, Levin NJ, Shields MJ, Parish M, Murphy RE, Del Rosario J, Oates BD, Lai JY, Matin MJ, Ainekulu Z, Bhat A, Bradshaw CW, Woodnutt G, Lerner RA, Lappe RW. Doppalapudi VR, et al. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22611-6. doi: 10.1073/pnas.1016478108. Epub 2010 Dec 13. Proc Natl Acad Sci U S A. 2010. PMID: 21149738 Free PMC article.
Penicillin sulfone inhibitors of class D beta-lactamases.
Drawz SM, Bethel CR, Doppalapudi VR, Sheri A, Pagadala SR, Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA. Drawz SM, et al. Among authors: doppalapudi vr. Antimicrob Agents Chemother. 2010 Apr;54(4):1414-24. doi: 10.1128/AAC.00743-09. Epub 2010 Jan 19. Antimicrob Agents Chemother. 2010. PMID: 20086146 Free PMC article.
Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies.
Doppalapudi VR, Tryder N, Li L, Aja T, Griffith D, Liao FF, Roxas G, Ramprasad MP, Bradshaw C, Barbas CF 3rd. Doppalapudi VR, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):501-6. doi: 10.1016/j.bmcl.2006.10.009. Epub 2006 Oct 7. Bioorg Med Chem Lett. 2007. PMID: 17055724
17 results