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GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system.
Asundi J, Zhang C, Donnelly-Roberts D, Solorio JZ, Challagundla M, Connelly C, Boch C, Chen J, Richter M, Maneshi MM, Swensen AM, Lebon L, Schiffmann R, Sanyal S, Sidrauski C, Kolumam G, Baruch A. Asundi J, et al. Among authors: donnelly roberts d. CNS Neurosci Ther. 2024 Feb;30(2):e14600. doi: 10.1111/cns.14600. CNS Neurosci Ther. 2024. PMID: 38357857 Free PMC article.
NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation.
Goess C, Terrillon S, Mayo M, Bousquet P, Wallace C, Hart M, Mathieu S, Twomey R, Donnelly-Roberts D, Namovic M, Jung P, Hu M, Richardson P, Esbenshade T, Cuff CA. Goess C, et al. Among authors: donnelly roberts d. J Transl Autoimmun. 2020 Dec 23;4:100079. doi: 10.1016/j.jtauto.2020.100079. eCollection 2021. J Transl Autoimmun. 2020. PMID: 33490940 Free PMC article.
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Dietrich JD, Longenecker KL, Wilson NS, Goess C, Panchal SC, Swann SL, Petros AM, Hobson AD, Ihle D, Song D, Richardson P, Comess KM, Cox PB, Dombrowski A, Sarris K, Donnelly-Roberts DL, Duignan DB, Gomtsyan A, Jung P, Krueger AC, Mathieu S, McClure A, Stoll VS, Wetter J, Mankovich JA, Hajduk PJ, Vasudevan A, Stoffel RH, Sun C. Dietrich JD, et al. Among authors: donnelly roberts dl. J Med Chem. 2021 Jan 14;64(1):417-429. doi: 10.1021/acs.jmedchem.0c01280. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33378180
Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses.
Slivka PF, Hsieh CL, Lipovsky A, Pratt SD, Locklear J, Namovic MT, McDonald HA, Wetter J, Edelmayer R, Hu M, Murphy E, Domanus M, Lu C, Duggan R, King J, Scott VE, Donnelly-Roberts D, Slavin A, Gopalakrishnan S, Chung N, Goedken ER. Slivka PF, et al. Among authors: donnelly roberts d. ACS Chem Biol. 2019 May 17;14(5):857-872. doi: 10.1021/acschembio.8b00260. Epub 2019 Apr 15. ACS Chem Biol. 2019. PMID: 30938974
eIF2B activator prevents neurological defects caused by a chronic integrated stress response.
Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND, Krishnan S, McAllister FE, Haste NV, O'Brien JJ, Roy M, Ireland A, Frost JM, Shi L, Riedmaier S, Martin K, Dart MJ, Sidrauski C. Wong YL, et al. Among authors: donnelly roberts dl. Elife. 2019 Jan 9;8:e42940. doi: 10.7554/eLife.42940. Elife. 2019. PMID: 30624206 Free PMC article.
Losartan improves renal function and pathology in obese ZSF-1 rats.
Su Z, Widomski D, Nikkel A, Leys L, Namovic M, Donnelly-Roberts D, Gopalakrishnan M, McGaraughty S. Su Z, et al. Among authors: donnelly roberts d. J Basic Clin Physiol Pharmacol. 2018 Jun 27;29(3):281-290. doi: 10.1515/jbcpp-2017-0157. J Basic Clin Physiol Pharmacol. 2018. PMID: 29397387
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