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Ursolic acid acetate and iso-mukaadial acetate bind to Plasmodium falciparum Hsp90, abrogating its chaperone function in vitro.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan 22. doi: 10.1007/s00210-024-02944-9. Online ahead of print.
Naunyn Schmiedebergs Arch Pharmacol. 2024.
PMID: 38252299
Insertion of GGMP repeat residues of Plasmodium falciparum Hsp70-1 in the lid of DnaK adversely impacts client recognition.
Dongola TH, Chakafana G, Middlemiss C, Mafethe O, Mokoena F, Zininga T, Shonhai A.
Dongola TH, et al.
Int J Biol Macromol. 2024 Jan;255:128070. doi: 10.1016/j.ijbiomac.2023.128070. Epub 2023 Nov 18.
Int J Biol Macromol. 2024.
PMID: 37981279
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Pharmacophore Model-Based Virtual Screening Workflow for Discovery of Inhibitors Targeting Plasmodium falciparum Hsp90.
Mafethe O, Ntseane T, Dongola TH, Shonhai A, Gumede NJ, Mokoena F.
Mafethe O, et al. Among authors: dongola th.
ACS Omega. 2023 Sep 26;8(41):38220-38232. doi: 10.1021/acsomega.3c04494. eCollection 2023 Oct 17.
ACS Omega. 2023.
PMID: 37867657
Free PMC article.
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Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro.
Ramatsui L, Dongola TH, Zininga T, Multhoff G, Shonhai A.
Ramatsui L, et al. Among authors: dongola th.
Cell Stress Chaperones. 2023 May;28(3):321-331. doi: 10.1007/s12192-023-01339-8. Epub 2023 Apr 19.
Cell Stress Chaperones. 2023.
PMID: 37074531
Free PMC article.
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Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide.
Muthelo T, Mulaudzi V, Netshishivhe M, Dongola TH, Kok M, Makumire S, de Villiers M, Burger A, Zininga T, Shonhai A.
Muthelo T, et al. Among authors: dongola th.
Front Mol Biosci. 2022 Sep 13;9:947203. doi: 10.3389/fmolb.2022.947203. eCollection 2022.
Front Mol Biosci. 2022.
PMID: 36177352
Free PMC article.
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Mutation of GGMP Repeat Segments of Plasmodium falciparum Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding.
Makumire S, Dongola TH, Chakafana G, Tshikonwane L, Chauke CT, Maharaj T, Zininga T, Shonhai A.
Makumire S, et al. Among authors: dongola th.
Int J Mol Sci. 2021 Feb 23;22(4):2226. doi: 10.3390/ijms22042226.
Int J Mol Sci. 2021.
PMID: 33672387
Free PMC article.
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