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Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination.
Checa-Rodríguez C, Cepeda-García C, Ramón J, López-Saavedra A, Balestra FR, Domínguez-Sánchez MS, Gómez-Cabello D, Huertas P. Checa-Rodríguez C, et al. Among authors: dominguez sanchez ms. DNA Repair (Amst). 2020 Oct;94:102902. doi: 10.1016/j.dnarep.2020.102902. Epub 2020 Jun 27. DNA Repair (Amst). 2020. PMID: 32623319 Free article.
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection.
López-Saavedra A, Gómez-Cabello D, Domínguez-Sánchez MS, Mejías-Navarro F, Fernández-Ávila MJ, Dinant C, Martínez-Macías MI, Bartek J, Huertas P. López-Saavedra A, et al. Among authors: dominguez sanchez ms. Nat Commun. 2016 Aug 9;7:12364. doi: 10.1038/ncomms12364. Nat Commun. 2016. PMID: 27503537 Free PMC article.