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Defining trained immunity and its role in health and disease.
Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. Netea MG, et al. Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4. Nat Rev Immunol. 2020. PMID: 32132681 Free PMC article. Review.
Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis.
Domínguez-Andrés J, Arts RJW, Ter Horst R, Gresnigt MS, Smeekens SP, Ratter JM, Lachmandas E, Boutens L, van de Veerdonk FL, Joosten LAB, Notebaart RA, Ardavín C, Netea MG. Domínguez-Andrés J, et al. PLoS Pathog. 2017 Sep 18;13(9):e1006632. doi: 10.1371/journal.ppat.1006632. eCollection 2017 Sep. PLoS Pathog. 2017. PMID: 28922415 Free PMC article.
Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A. Alsina-Beauchamp D, et al. EMBO Mol Med. 2018 May;10(5):e8485. doi: 10.15252/emmm.201708485. EMBO Mol Med. 2018. PMID: 29661910 Free PMC article.
Long-term reprogramming of the innate immune system.
Dominguez-Andres J, Netea MG. Dominguez-Andres J, et al. J Leukoc Biol. 2019 Feb;105(2):329-338. doi: 10.1002/JLB.MR0318-104R. Epub 2018 Jul 12. J Leukoc Biol. 2019. PMID: 29999546 Review.
The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.
Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG. Domínguez-Andrés J, et al. Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4. Cell Metab. 2019. PMID: 30293776 Free article.
Itaconate as an immune modulator.
Ferreira AV, Netea MG, Domínguez-Andrés J. Ferreira AV, et al. Aging (Albany NY). 2019 Jun 24;11(12):3898-3899. doi: 10.18632/aging.102057. Aging (Albany NY). 2019. PMID: 31235675 Free PMC article. No abstract available.
71 results