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Calcium currents are enhanced by α2δ-1 lacking its membrane anchor.
Kadurin I, Alvarez-Laviada A, Ng SF, Walker-Gray R, D'Arco M, Fadel MG, Pratt WS, Dolphin AC. Kadurin I, et al. Among authors: dolphin ac. J Biol Chem. 2012 Sep 28;287(40):33554-66. doi: 10.1074/jbc.M112.378554. Epub 2012 Aug 6. J Biol Chem. 2012. PMID: 22869375 Free PMC article.
The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function.
Brodbeck J, Davies A, Courtney JM, Meir A, Balaguero N, Canti C, Moss FJ, Page KM, Pratt WS, Hunt SP, Barclay J, Rees M, Dolphin AC. Brodbeck J, et al. Among authors: dolphin ac. J Biol Chem. 2002 Mar 8;277(10):7684-93. doi: 10.1074/jbc.M109404200. Epub 2001 Dec 26. J Biol Chem. 2002. PMID: 11756448 Free article.
234 results