Doench JG - Search Results

1

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.

Dubrot J, Du PP, Lane-Reticker SK, Kessler EA, Muscato AJ, Mehta A, Freeman SS, Allen PM, Olander KE, Ockerman KM, Wolfe CH, Wiesmann F, Knudsen NH, Tsao HW, Iracheta-Vellve A, Schneider EM, Rivera-Rosario AN, Kohnle IC, Pope HW, Ayer A, Mishra G, Zimmer MD, Kim SY, Mahapatra A, Ebrahimi-Nik H, Frederick DT, Boland GM, Haining WN, Root DE, Doench JG, Hacohen N, Yates KB, Manguso RT. Dubrot J, et al. Among authors: doench jg. Nat Immunol. 2022 Oct;23(10):1495-1506. doi: 10.1038/s41590-022-01315-x. Epub 2022 Sep 23. Nat Immunol. 2022. PMID: 36151395

2

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.

Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Lee MN, et al. Among authors: doench jg. Nat Immunol. 2013 Feb;14(2):179-85. doi: 10.1038/ni.2509. Epub 2012 Dec 23. Nat Immunol. 2013. PMID: 23263557 Free PMC article.

3

Genome-scale CRISPR-Cas9 knockout screening in human cells.

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Shalem O, et al. Among authors: doench jg. Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12. Science. 2014. PMID: 24336571 Free PMC article.

4

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P. Zhao B, et al. Among authors: doench jg. Haematologica. 2014 Jul;99(7):1157-67. doi: 10.3324/haematol.2014.105809. Epub 2014 Apr 18. Haematologica. 2014. PMID: 24747950 Free PMC article.

5

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE. Doench JG, et al. Nat Biotechnol. 2014 Dec;32(12):1262-7. doi: 10.1038/nbt.3026. Epub 2014 Sep 3. Nat Biotechnol. 2014. PMID: 25184501 Free PMC article.

6

HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.

Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. Wein MN, et al. J Bone Miner Res. 2015 Mar;30(3):400-11. doi: 10.1002/jbmr.2381. J Bone Miner Res. 2015. PMID: 25271055 Free PMC article.

7

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA. Chen CW, et al. Among authors: doench jg. Nat Med. 2015 Apr;21(4):335-43. doi: 10.1038/nm.3832. Epub 2015 Mar 30. Nat Med. 2015. PMID: 25822366 Free PMC article.

8

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng ACY, Doench JG, Root DE, Clish CB, Xavier RJ. Graham DB, et al. Among authors: doench jg. Nat Commun. 2015 Jul 21;6:7838. doi: 10.1038/ncomms8838. Nat Commun. 2015. PMID: 26194095 Free PMC article.

9

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.

Singh S, Wu X, Ljosa V, Bray MA, Piccioni F, Root DE, Doench JG, Boehm JS, Carpenter AE. Singh S, et al. Among authors: doench jg. PLoS One. 2015 Jul 21;10(7):e0131370. doi: 10.1371/journal.pone.0131370. eCollection 2015. PLoS One. 2015. PMID: 26197079 Free PMC article.

10

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE. Doench JG, et al. Nat Biotechnol. 2016 Feb;34(2):184-191. doi: 10.1038/nbt.3437. Epub 2016 Jan 18. Nat Biotechnol. 2016. PMID: 26780180 Free PMC article.

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