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High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs.
Knezevic L, Wachsmann TLA, Francis O, Dockree T, Bridgeman JS, Wouters A, de Wet B, Cole DK, Clement M, McLaren JE, Gostick E, Ladell K, Llewellyn-Lacey S, Price DA, van den Berg HA, Tabi Z, Sessions RB, Heemskerk MHM, Wooldridge L. Knezevic L, et al. Among authors: dockree t. J Biol Chem. 2023 Aug;299(8):104981. doi: 10.1016/j.jbc.2023.104981. Epub 2023 Jun 28. J Biol Chem. 2023. PMID: 37390984 Free PMC article.
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Dockree T, Holland CJ, Clement M, Ladell K, McLaren JE, van den Berg HA, Gostick E, L Miners K, Llewellyn-Lacey S, Bridgeman JS, Man S, Bailey M, Burrows SR, Price DA, Wooldridge L. Dockree T, et al. Immunol Cell Biol. 2017 Jan;95(1):68-76. doi: 10.1038/icb.2016.85. Epub 2016 Nov 8. Immunol Cell Biol. 2017. PMID: 27670790 Free PMC article.
Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.
Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L. Clement M, et al. Among authors: dockree t. Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332. Sci Rep. 2016. PMID: 27748447 Free PMC article.
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Clement M, Knezevic L, Dockree T, McLaren JE, Ladell K, Miners KL, Llewellyn-Lacey S, Rubina A, Francis O, Cole DK, Sewell AK, Bridgeman JS, Price DA, van den Berg HA, Wooldridge L. Clement M, et al. Among authors: dockree t. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2019639118. doi: 10.1073/pnas.2019639118. Proc Natl Acad Sci U S A. 2021. PMID: 34272276 Free PMC article.