Dinkova-Kostova AT - Search Results

1

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.

Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT. Cuadrado A, et al. Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Nat Rev Drug Discov. 2019. PMID: 30610225 Review.

2

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.

3

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.

Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Fahey JW, et al. Carcinogenesis. 2005 Jul;26(7):1247-55. doi: 10.1093/carcin/bgi068. Epub 2005 Mar 17. Carcinogenesis. 2005. PMID: 15774490

4

The role of Keap1 in cellular protective responses.

Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.

5

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MS, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K. Cornblatt BS, et al. Carcinogenesis. 2007 Jul;28(7):1485-90. doi: 10.1093/carcin/bgm049. Epub 2007 Mar 7. Carcinogenesis. 2007. PMID: 17347138

6

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

Hayes JD, Dinkova-Kostova AT, McMahon M. Hayes JD, et al. Toxicol Sci. 2009 Oct;111(2):199-201. doi: 10.1093/toxsci/kfp168. Epub 2009 Jul 23. Toxicol Sci. 2009. PMID: 19628587 No abstract available.

7

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD. Chowdhry S, et al. Free Radic Biol Med. 2010 Jan 15;48(2):357-71. doi: 10.1016/j.freeradbiomed.2009.11.007. Epub 2009 Nov 13. Free Radic Biol Med. 2010. PMID: 19914374

8

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT. Wang XJ, et al. Chem Biol. 2010 Jan 29;17(1):75-85. doi: 10.1016/j.chembiol.2009.12.013. Chem Biol. 2010. PMID: 20142043

9

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.

Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT. Hayes JD, et al. Antioxid Redox Signal. 2010 Dec 1;13(11):1713-48. doi: 10.1089/ars.2010.3221. Epub 2010 Aug 14. Antioxid Redox Signal. 2010. PMID: 20446772 Review.

10

Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols.

Dinkova-Kostova AT, Wang XJ. Dinkova-Kostova AT, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):101-6. doi: 10.1016/j.cbi.2010.09.010. Epub 2010 Sep 21. Chem Biol Interact. 2011. PMID: 20846517

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