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Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
Heinrich T, Peterson C, Schneider R, Garg S, Schwarz D, Gunera J, Seshire A, Kötzner L, Schlesiger S, Musil D, Schilke H, Doerfel B, Diehl P, Böpple P, Lemos AR, Sousa PMF, Freire F, Bandeiras TM, Carswell E, Pearson N, Sirohi S, Hooker M, Trivier E, Broome R, Balsiger A, Crowden A, Dillon C, Wienke D. Heinrich T, et al. Among authors: dillon c. J Med Chem. 2022 Jul 14;65(13):9206-9229. doi: 10.1021/acs.jmedchem.2c00403. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35763499
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A. Boege Y, et al. Among authors: dillon c. Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010. Cancer Cell. 2017. PMID: 28898696 Free PMC article.
Ripped to death.
Weinlich R, Dillon CP, Green DR. Weinlich R, et al. Trends Cell Biol. 2011 Nov;21(11):630-7. doi: 10.1016/j.tcb.2011.09.002. Epub 2011 Oct 4. Trends Cell Biol. 2011. PMID: 21978761 Free PMC article. Review.
Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR. Dillon CP, et al. Cell Rep. 2012 May 31;1(5):401-7. doi: 10.1016/j.celrep.2012.03.010. Cell Rep. 2012. PMID: 22675671 Free PMC article.
Protective roles for caspase-8 and cFLIP in adult homeostasis.
Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR. Weinlich R, et al. Among authors: dillon cp. Cell Rep. 2013 Oct 31;5(2):340-8. doi: 10.1016/j.celrep.2013.08.045. Epub 2013 Oct 3. Cell Rep. 2013. PMID: 24095739 Free PMC article.
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR. Dillon CP, et al. Cell. 2014 May 22;157(5):1189-202. doi: 10.1016/j.cell.2014.04.018. Epub 2014 May 8. Cell. 2014. PMID: 24813850 Free PMC article.
385 results