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The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. Müller A, et al. Among authors: dickmanns a. J Clin Invest. 2020 Nov 2;130(11):5765-5781. doi: 10.1172/JCI134217. J Clin Invest. 2020. PMID: 32701505 Free PMC article.
p63 antagonizes Wnt-induced transcription.
Drewelus I, Göpfert C, Hippel C, Dickmanns A, Damianitsch K, Pieler T, Dobbelstein M. Drewelus I, et al. Among authors: dickmanns a. Cell Cycle. 2010 Feb 1;9(3):580-87. doi: 10.4161/cc.9.3.10593. Cell Cycle. 2010. PMID: 20107313
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. Wienken M, et al. Among authors: dickmanns a. Mol Cell. 2016 Jan 7;61(1):68-83. doi: 10.1016/j.molcel.2015.12.008. Epub 2015 Dec 31. Mol Cell. 2016. PMID: 26748827 Free PMC article.
CDK4 inhibition diminishes p53 activation by MDM2 antagonists.
Sriraman A, Dickmanns A, Najafova Z, Johnsen SA, Dobbelstein M. Sriraman A, et al. Among authors: dickmanns a. Cell Death Dis. 2018 Sep 11;9(9):918. doi: 10.1038/s41419-018-0968-0. Cell Death Dis. 2018. PMID: 30206211 Free PMC article.
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Stegmann KM, Dickmanns A, Gerber S, Nikolova V, Klemke L, Manzini V, Schlösser D, Bierwirth C, Freund J, Sitte M, Lugert R, Salinas G, Meister TL, Pfaender S, Görlich D, Wollnik B, Groß U, Dobbelstein M. Stegmann KM, et al. Among authors: dickmanns a. Virus Res. 2021 Sep;302:198469. doi: 10.1016/j.virusres.2021.198469. Epub 2021 Jun 6. Virus Res. 2021. PMID: 34090962 Free PMC article.
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.
Güttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, Taxer W, Rymarenko O, Schünemann J, Dienemann C, Gunkel P, Mussil B, Krull J, Teichmann U, Groß U, Cordes VC, Dobbelstein M, Görlich D. Güttler T, et al. Among authors: dickmanns a. EMBO J. 2021 Oct 1;40(19):e107985. doi: 10.15252/embj.2021107985. Epub 2021 Aug 9. EMBO J. 2021. PMID: 34302370 Free PMC article.
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
Stegmann KM, Dickmanns A, Heinen N, Blaurock C, Karrasch T, Breithaupt A, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Herrmann ST, Schreieck A, Peelen E, Kohlhof H, Sadeghi B, Riek A, Speakman JR, Groß U, Görlich D, Vitt D, Müller T, Grunwald T, Pfaender S, Balkema-Buschmann A, Dobbelstein M. Stegmann KM, et al. Among authors: dickmanns a. iScience. 2022 May 20;25(5):104293. doi: 10.1016/j.isci.2022.104293. Epub 2022 Apr 25. iScience. 2022. PMID: 35492218 Free PMC article.
MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression.
Giansanti C, Manzini V, Dickmanns A, Dickmanns A, Palumbieri MD, Sanchi A, Kienle SM, Rieth S, Scheffner M, Lopes M, Dobbelstein M. Giansanti C, et al. Among authors: dickmanns a. Cell Rep. 2022 May 31;39(9):110879. doi: 10.1016/j.celrep.2022.110879. Cell Rep. 2022. PMID: 35649362 Free article.
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody.
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein AW, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M. Zibat A, et al. Among authors: dickmanns a. iScience. 2023 Aug 30;26(10):107786. doi: 10.1016/j.isci.2023.107786. eCollection 2023 Oct 20. iScience. 2023. PMID: 37731621 Free PMC article.
83 results