Dick T - Search Results

1

Targeted protein degradation in antibacterial drug discovery?

Gopal P, Dick T. Gopal P, et al. Among authors: dick t. Prog Biophys Mol Biol. 2020 May;152:10-14. doi: 10.1016/j.pbiomolbio.2019.11.005. Epub 2019 Nov 16. Prog Biophys Mol Biol. 2020. PMID: 31738980 Free PMC article. Review.

2

Reactive dirty fragments: implications for tuberculosis drug discovery.

Gopal P, Dick T. Gopal P, et al. Among authors: dick t. Curr Opin Microbiol. 2014 Oct;21:7-12. doi: 10.1016/j.mib.2014.06.015. Epub 2014 Jul 30. Curr Opin Microbiol. 2014. PMID: 25078318 Free article. Review.

3

Antibacterial drug discovery: doing it right.

Gengenbacher M, Dick T. Gengenbacher M, et al. Among authors: dick t. Chem Biol. 2015 Jan 22;22(1):5-6. doi: 10.1016/j.chembiol.2014.12.005. Chem Biol. 2015. PMID: 25615950

4

The new tuberculosis drug Perchlozone® shows cross-resistance with thiacetazone.

Gopal P, Dick T. Gopal P, et al. Among authors: dick t. Int J Antimicrob Agents. 2015 Apr;45(4):430-3. doi: 10.1016/j.ijantimicag.2014.12.026. Epub 2015 Feb 3. Int J Antimicrob Agents. 2015. PMID: 25704063

5

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.

Gopal P, Yee M, Sarathy J, Low JL, Sarathy JP, Kaya F, Dartois V, Gengenbacher M, Dick T. Gopal P, et al. Among authors: dick t. ACS Infect Dis. 2016 Sep 9;2(9):616-626. doi: 10.1021/acsinfecdis.6b00070. Epub 2016 Aug 8. ACS Infect Dis. 2016. PMID: 27759369 Free PMC article.

6

Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.

Yee M, Gopal P, Dick T. Yee M, et al. Among authors: dick t. Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02342-16. doi: 10.1128/AAC.02342-16. Print 2017 Feb. Antimicrob Agents Chemother. 2017. PMID: 27872068 Free PMC article.

7

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.

Gopal P, Tasneen R, Yee M, Lanoix JP, Sarathy J, Rasic G, Li L, Dartois V, Nuermberger E, Dick T. Gopal P, et al. Among authors: dick t. ACS Infect Dis. 2017 Jul 14;3(7):492-501. doi: 10.1021/acsinfecdis.7b00017. Epub 2017 Mar 16. ACS Infect Dis. 2017. PMID: 28271875 Free PMC article.

8

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.

Gopal P, Nartey W, Ragunathan P, Sarathy J, Kaya F, Yee M, Setzer C, Manimekalai MSS, Dartois V, Grüber G, Dick T. Gopal P, et al. Among authors: dick t. ACS Infect Dis. 2017 Nov 10;3(11):807-819. doi: 10.1021/acsinfecdis.7b00079. Epub 2017 Oct 18. ACS Infect Dis. 2017. PMID: 28991455 Free PMC article.

9

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents.

Li M, Nyantakyi SA, Gopal P, Aziz DB, Dick T, Go ML. Li M, et al. Among authors: dick t. ACS Med Chem Lett. 2017 Oct 9;8(11):1165-1170. doi: 10.1021/acsmedchemlett.7b00287. eCollection 2017 Nov 9. ACS Med Chem Lett. 2017. PMID: 29152049 Free PMC article.

10

NTM drug discovery: status, gaps and the way forward.

Wu ML, Aziz DB, Dartois V, Dick T. Wu ML, et al. Among authors: dick t. Drug Discov Today. 2018 Aug;23(8):1502-1519. doi: 10.1016/j.drudis.2018.04.001. Epub 2018 Apr 7. Drug Discov Today. 2018. PMID: 29635026 Free PMC article. Review.

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