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Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1.
Comp Med. 2013 Aug;63(4):331-7.
Comp Med. 2013.
PMID: 24209968
Free PMC article.
Leukotoxin (Leukothera®) targets active leukocyte function antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway.
DiFranco KM, Gupta A, Galusha LE, Perez J, Nguyen TK, Fineza CD, Kachlany SC.
DiFranco KM, et al.
J Biol Chem. 2012 May 18;287(21):17618-17627. doi: 10.1074/jbc.M111.314674. Epub 2012 Mar 30.
J Biol Chem. 2012.
PMID: 22467872
Free PMC article.
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LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.
DiFranco KM, Johnson-Farley N, Bertino JR, Elson D, Vega BA, Belinka BA Jr, Kachlany SC.
DiFranco KM, et al.
Leuk Res. 2015 Jun;39(6):649-56. doi: 10.1016/j.leukres.2015.03.010. Epub 2015 Mar 21.
Leuk Res. 2015.
PMID: 25850729
Free PMC article.
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Induction of CFTR gene expression by 1,25(OH)2 vitamin D3, 25OH vitamin D3, and vitamin D3 in cultured human airway epithelial cells and in mouse airways.
DiFranco KM, Mulligan JK, Sumal AS, Diamond G.
DiFranco KM, et al.
J Steroid Biochem Mol Biol. 2017 Oct;173:323-332. doi: 10.1016/j.jsbmb.2017.01.013. Epub 2017 Jan 24.
J Steroid Biochem Mol Biol. 2017.
PMID: 28130182
Free PMC article.
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Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism.
Menzel LP, Chowdhury HM, Masso-Silva JA, Ruddick W, Falkovsky K, Vorona R, Malsbary A, Cherabuddi K, Ryan LK, DiFranco KM, Brice DC, Costanzo MJ, Weaver D, Freeman KB, Scott RW, Diamond G.
Menzel LP, et al. Among authors: difranco km.
Sci Rep. 2017 Jun 28;7(1):4353. doi: 10.1038/s41598-017-04462-6.
Sci Rep. 2017.
PMID: 28659617
Free PMC article.
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Surface display of Aggregatibacter actinomycetemcomitans autotransporter Aae and dispersin B hybrid act as antibiofilm agents.
Ragunath C, DiFranco K, Shanmugam M, Gopal P, Vyas V, Fine DH, Cugini C, Ramasubbu N.
Ragunath C, et al.
Mol Oral Microbiol. 2016 Aug;31(4):329-39. doi: 10.1111/omi.12126. Epub 2015 Sep 22.
Mol Oral Microbiol. 2016.
PMID: 26280561
Free PMC article.
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