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1955 1
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1970 7
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1972 24
1973 59
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Page 1
Showing results for deplete t
Search for Detente T instead (2 results)
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody.
Weaver JD, Stack EC, Buggé JA, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu CA, Krukenberg K, Zhang Y, Ezzyat Y, Saddier Axe D, Kuhne MR, Meehl MA, Shaffer DR, Weist BM, Wiederschain D, Depis F, Gostissa M. Weaver JD, et al. Oncoimmunology. 2022 Nov 4;11(1):2141007. doi: 10.1080/2162402X.2022.2141007. eCollection 2022. Oncoimmunology. 2022. PMID: 36352891 Free PMC article.
Therefore, depletion of tumor-infiltrating Tregs is a potential approach to overcome resistance to immunotherapy. ...Here, we describe GS-1811, a novel therapeutic monoclonal antibody that specifically binds to human CCR8 and is designed to selectively deplete tumor …
Therefore, depletion of tumor-infiltrating Tregs is a potential approach to overcome resistance to immunotherapy. ...Here, we describ …
Depleting T-cell subpopulations in organ transplantation.
Haudebourg T, Poirier N, Vanhove B. Haudebourg T, et al. Transpl Int. 2009 May;22(5):509-18. doi: 10.1111/j.1432-2277.2008.00788.x. Epub 2008 Oct 30. Transpl Int. 2009. PMID: 18980625 Free article. Review.
T-cell depletion strategies are an efficient therapy for the treatment of acute rejection after organ transplantation and have been successfully used as induction regimens. Although eliminating whole T cells blocks alloreactivity, this therapy challenges the …
T-cell depletion strategies are an efficient therapy for the treatment of acute rejection after organ transplantation and have …
Haploidentical stem cell transplantation: T cell depleted and repleted.
Gokgoz Z, Arslan O. Gokgoz Z, et al. Transfus Apher Sci. 2018 Apr;57(2):171-173. doi: 10.1016/j.transci.2018.04.016. Epub 2018 Apr 19. Transfus Apher Sci. 2018. PMID: 29706356 Review.
More than half of the patients do not have a HLA fully matched related/unrelated donor but almost all patients have an haploidentical donor. Haploidentical transplantion can be performed either as T cell depleted or repleted. Despite the promising results in T …
More than half of the patients do not have a HLA fully matched related/unrelated donor but almost all patients have an haploidentical donor. …
Treatment with immunotoxin.
Knechtle SJ. Knechtle SJ. Philos Trans R Soc Lond B Biol Sci. 2001 May 29;356(1409):681-9. doi: 10.1098/rstb.2001.0839. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11375071 Free PMC article. Review.
Both total lymphoid irradiation and anti-lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However, these methods of T-cell depletion are limited in their ability to depl …
Both total lymphoid irradiation and anti-lymphocyte globulin have been used for this purpose in experimental models of transplantation as we …
CD25-targeted antibody-drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity.
Zammarchi F, Havenith K, Bertelli F, Vijayakrishnan B, Chivers S, van Berkel PH. Zammarchi F, et al. J Immunother Cancer. 2020 Sep;8(2):e000860. doi: 10.1136/jitc-2020-000860. J Immunother Cancer. 2020. PMID: 32912922 Free PMC article.
Numerous strategies have been attempted to deplete or block T(regs), although their success has been limited. ...This represents a novel approach to efficiently deplete T(regs) via a very potent DNA damaging toxin known to induce immunogenic cell death …
Numerous strategies have been attempted to deplete or block T(regs), although their success has been limited. ...This represen …
T-cell depleting antibodies: new hope for induction of allograft tolerance in bone marrow transplantation?
Simpson D. Simpson D. BioDrugs. 2003;17(3):147-54. doi: 10.2165/00063030-200317030-00001. BioDrugs. 2003. PMID: 12749751 Review.
Alternative approaches are needed. In vivo T-cell depletion, using antithymocyte globulin (ATG) as part of the conditioning regimen, seems an attractive option. Pre-transplant ATG lingers in the bone marrow to deplete engrafting donor T cells, but also …
Alternative approaches are needed. In vivo T-cell depletion, using antithymocyte globulin (ATG) as part of the conditioning re …
Variances in Antiviral Memory T-Cell Repertoire of CD45RA- and CD62L-Depleted Lymphocyte Products Reflect the Need of Individual T-Cell Selection Strategies to Reduce the Risk of GvHD while Preserving Antiviral Immunity in Adoptive T-Cell Therapy.
Mangare C, Tischer-Zimmermann S, Bonifacius A, Riese SB, Dragon AC, Blasczyk R, Maecker-Kolhoff B, Eiz-Vesper B. Mangare C, et al. Transfus Med Hemother. 2021 Sep 10;49(1):30-43. doi: 10.1159/000516284. eCollection 2022 Feb. Transfus Med Hemother. 2021. PMID: 35221866 Free PMC article.
CONCLUSION: Taken together, our results indicate that CD45RA depletion is a more suitable strategy for generating T(N)-depleted products consisting of memory T cells against ppEBV_EBNA1 and ppAdV_Hexon than CD62L in terms of depletion effectiven …
CONCLUSION: Taken together, our results indicate that CD45RA depletion is a more suitable strategy for generating T(N)-depl …
Regulatory T cells specifically suppress conventional CD8alphabeta T cells in intestinal tumors of APC(Min/+) mice.
Szeponik L, Akeus P, Rodin W, Raghavan S, Quiding-Järbrink M. Szeponik L, et al. Cancer Immunol Immunother. 2020 Jul;69(7):1279-1292. doi: 10.1007/s00262-020-02540-9. Epub 2020 Mar 17. Cancer Immunol Immunother. 2020. PMID: 32185408 Free PMC article.
In sharp contrast, the densities and effector functions of TCRalphabeta(+)CD8alphaalpha(+) T cells and TCRgammadelta(+) T cells remained unchanged by Treg depletion. We also documented a distinct population of IL-17A(+)TNF(+) TCRgammadelta(+)CD8(-) T c …
In sharp contrast, the densities and effector functions of TCRalphabeta(+)CD8alphaalpha(+) T cells and TCRgammadelta(+) T cell …
Regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function.
Negera E, Bobosha K, Aseffa A, Dockrell HM, Lockwood DNJ, Walker SL. Negera E, et al. PLoS Negl Trop Dis. 2022 Jul 22;16(7):e0010641. doi: 10.1371/journal.pntd.0010641. eCollection 2022 Jul. PLoS Negl Trop Dis. 2022. PMID: 35867720 Free PMC article.
The addition of autologous CD25+ cells to CD25+ depleted PBMCs abolished these responses. In both non-reactional LL and ENL groups mitogen (PHA)-induced TNFalpha and IFNgamma responses were not affected by depletion of CD25+ cells either before or after treatment. …
The addition of autologous CD25+ cells to CD25+ depleted PBMCs abolished these responses. In both non-reactional LL and ENL groups mi …
In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells.
Koenecke C, Chennupati V, Schmitz S, Malissen B, Förster R, Prinz I. Koenecke C, et al. Eur J Immunol. 2009 Feb;39(2):372-9. doi: 10.1002/eji.200838741. Eur J Immunol. 2009. PMID: 19130484 Free article.
mAb targeting the gammadelta TCR have been used for gammadelta T-cell depletion with varying success. Although the depletion-capacity of the anti-gammadelta TCR mAb clone GL3 has been disputed repeatedly, many groups continue to use gammadelta T-cell …
mAb targeting the gammadelta TCR have been used for gammadelta T-cell depletion with varying success. Although the depletio …
156,146 results
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