Deshpande RA - Search Results

1

METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.

Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. Zeng X, et al. Among authors: deshpande ra. Nat Cancer. 2022 Sep;3(9):1088-1104. doi: 10.1038/s43018-022-00429-3. Epub 2022 Sep 22. Nat Cancer. 2022. PMID: 36138131

2

ATM activation in the presence of oxidative stress.

Guo Z, Deshpande R, Paull TT. Guo Z, et al. Cell Cycle. 2010 Dec 15;9(24):4805-11. doi: 10.4161/cc.9.24.14323. Epub 2010 Dec 15. Cell Cycle. 2010. PMID: 21150274 Free PMC article.

3

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT. Lee JH, et al. Among authors: deshpande ra. J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22. J Biol Chem. 2013. PMID: 23525106 Free PMC article.

4

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. Deshpande RA, et al. EMBO J. 2014 Mar 3;33(5):482-500. doi: 10.1002/embj.201386100. Epub 2014 Feb 3. EMBO J. 2014. PMID: 24493214 Free PMC article.

5

Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.

Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT. Makharashvili N, et al. Among authors: deshpande ra. Mol Cell. 2014 Jun 19;54(6):1022-1033. doi: 10.1016/j.molcel.2014.04.011. Epub 2014 May 15. Mol Cell. 2014. PMID: 24837676 Free PMC article.

6

The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes.

Paull TT, Deshpande RA. Paull TT, et al. Among authors: deshpande ra. Exp Cell Res. 2014 Nov 15;329(1):139-47. doi: 10.1016/j.yexcr.2014.07.007. Epub 2014 Jul 9. Exp Cell Res. 2014. PMID: 25016281 Free PMC article. Review.

7

EXD2 promotes homologous recombination by facilitating DNA end resection.

Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W. Broderick R, et al. Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25. Nat Cell Biol. 2016. PMID: 26807646 Free PMC article.

8

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Hoa NN, et al. Among authors: deshpande ra. Mol Cell. 2016 Nov 3;64(3):580-592. doi: 10.1016/j.molcel.2016.10.011. Mol Cell. 2016. PMID: 27814490 Free article.

9

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.

Deshpande RA, Lee JH, Arora S, Paull TT. Deshpande RA, et al. Mol Cell. 2016 Nov 3;64(3):593-606. doi: 10.1016/j.molcel.2016.10.010. Mol Cell. 2016. PMID: 27814491 Free article.

10

Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.

Deshpande RA, Lee JH, Paull TT. Deshpande RA, et al. Nucleic Acids Res. 2017 May 19;45(9):5255-5268. doi: 10.1093/nar/gkx173. Nucleic Acids Res. 2017. PMID: 28369545 Free PMC article.

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