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Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.
PLoS One. 2013 Dec 26;8(12):e83914. doi: 10.1371/journal.pone.0083914. eCollection 2013.
PLoS One. 2013.
PMID: 24386307
Free PMC article.
Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.
Lonskaya I, Hebron ML, Algarzae NK, Desforges N, Moussa CE.
Lonskaya I, et al.
Neuroscience. 2013 Mar 1;232:90-105. doi: 10.1016/j.neuroscience.2012.12.018. Epub 2012 Dec 20.
Neuroscience. 2013.
PMID: 23262240
Free PMC article.
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Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's disease.
Lonskaya I, Shekoyan AR, Hebron ML, Desforges N, Algarzae NK, Moussa CE.
Lonskaya I, et al.
J Alzheimers Dis. 2013;33(1):231-47. doi: 10.3233/JAD-2012-121141.
J Alzheimers Dis. 2013.
PMID: 22954671
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Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance.
Lonskaya I, Hebron ML, Desforges NM, Franjie A, Moussa CE.
Lonskaya I, et al. Among authors: desforges nm.
EMBO Mol Med. 2013 Aug;5(8):1247-62. doi: 10.1002/emmm.201302771. Epub 2013 Jul 4.
EMBO Mol Med. 2013.
PMID: 23737459
Free PMC article.
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Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance.
Lonskaya I, Hebron ML, Desforges NM, Schachter JB, Moussa CE.
Lonskaya I, et al. Among authors: desforges nm.
J Mol Med (Berl). 2014 Apr;92(4):373-86. doi: 10.1007/s00109-013-1112-3. Epub 2013 Dec 13.
J Mol Med (Berl). 2014.
PMID: 24337465
Free PMC article.
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Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases.
Desforges NM, Hebron ML, Algarzae NK, Lonskaya I, Moussa CE.
Desforges NM, et al.
Int J Alzheimers Dis. 2012;2012:345472. doi: 10.1155/2012/345472. Epub 2012 Aug 5.
Int J Alzheimers Dis. 2012.
PMID: 22919540
Free PMC article.
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