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Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor.
Deschaine SL, Hedegaard MA, Pince CL, Farokhnia M, Moose JE, Stock IA, Adusumalli S, Akhlaghi F, Hougland JL, Sulima A, Rice KC, Koob GF, Vendruscolo LF, Holst B, Leggio L. Deschaine SL, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):117-128. doi: 10.1124/jpet.122.001393. Epub 2023 Jan 11. J Pharmacol Exp Ther. 2023. PMID: 36631279 Free PMC article.
Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder.
Kärkkäinen O, Farokhnia M, Klåvus A, Auriola S, Lehtonen M, Deschaine SL, Piacentino D, Abshire KM, Jackson SN, Leggio L. Kärkkäinen O, et al. Among authors: deschaine sl. Alcohol Clin Exp Res. 2021 Nov;45(11):2207-2216. doi: 10.1111/acer.14719. Epub 2021 Sep 30. Alcohol Clin Exp Res. 2021. PMID: 34590334 Free PMC article. Clinical Trial.
A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data.
Deschaine SL, Farokhnia M, Gregory-Flores A, Zallar LJ, You ZB, Sun H, Harvey DM, Marchette RCN, Tunstall BJ, Mani BK, Moose JE, Lee MR, Gardner E, Akhlaghi F, Roberto M, Hougland JL, Zigman JM, Koob GF, Vendruscolo LF, Leggio L. Deschaine SL, et al. Addict Biol. 2022 Jan;27(1):e13033. doi: 10.1111/adb.13033. Epub 2021 Apr 27. Addict Biol. 2022. PMID: 33908131 Free PMC article. Clinical Trial.
Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study.
Farokhnia M, Abshire KM, Hammer A, Deschaine SL, Saravanakumar A, Cobbina E, You ZB, Haass-Koffler CL, Lee MR, Akhlaghi F, Leggio L. Farokhnia M, et al. Among authors: deschaine sl. Int J Neuropsychopharmacol. 2021 Jul 14;24(6):464-476. doi: 10.1093/ijnp/pyab004. Int J Neuropsychopharmacol. 2021. PMID: 33560411 Free PMC article. Clinical Trial.
Effects of exogenous ghrelin administration and ghrelin receptor blockade, in combination with alcohol, on peripheral inflammatory markers in heavy-drinking individuals: Results from two human laboratory studies.
Farokhnia M, Portelli J, Lee MR, McDiarmid GR, Munjal V, Abshire KM, Battista JT, Browning BD, Deschaine SL, Akhlaghi F, Leggio L. Farokhnia M, et al. Among authors: deschaine sl. Brain Res. 2020 Aug 1;1740:146851. doi: 10.1016/j.brainres.2020.146851. Epub 2020 Apr 24. Brain Res. 2020. PMID: 32339499 Free PMC article. Clinical Trial.
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