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PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells.
Denisova OV, Merisaari J, Huhtaniemi R, Qiao X, Yetukuri L, Jumppanen M, Kaur A, Pääkkönen M, von Schantz-Fant С, Ohlmeyer M, Wennerberg K, Kauko O, Koch R, Aittokallio T, Taipale M, Westermarck J. Denisova OV, et al. Mol Oncol. 2023 Sep;17(9):1803-1820. doi: 10.1002/1878-0261.13488. Epub 2023 Jul 26. Mol Oncol. 2023. PMID: 37458534 Free PMC article.
Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Merisaari J, Denisova OV, Doroszko M, Le Joncour V, Johansson P, Leenders WPJ, Kastrinsky DB, Zaware N, Narla G, Laakkonen P, Nelander S, Ohlmeyer M, Westermarck J. Merisaari J, et al. Among authors: denisova ov. Brain Commun. 2020 Jan 11;2(1):fcaa002. doi: 10.1093/braincomms/fcaa002. eCollection 2020. Brain Commun. 2020. PMID: 32954276 Free PMC article.
PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells.
Kaur A, Denisova OV, Qiao X, Jumppanen M, Peuhu E, Ahmed SU, Raheem O, Haapasalo H, Eriksson J, Chalmers AJ, Laakkonen P, Westermarck J. Kaur A, et al. Among authors: denisova ov. Cancer Res. 2016 Dec 1;76(23):7001-7011. doi: 10.1158/0008-5472.CAN-16-1134. Epub 2016 Sep 26. Cancer Res. 2016. PMID: 27671680
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.
Söderholm S, Kainov DE, Öhman T, Denisova OV, Schepens B, Kulesskiy E, Imanishi SY, Corthals G, Hintsanen P, Aittokallio T, Saelens X, Matikainen S, Nyman TA. Söderholm S, et al. Among authors: denisova ov. Mol Cell Proteomics. 2016 Oct;15(10):3203-3219. doi: 10.1074/mcp.M116.057984. Epub 2016 Aug 2. Mol Cell Proteomics. 2016. PMID: 27486199 Free PMC article.
Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.
Denisova OV, Söderholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE. Denisova OV, et al. Antimicrob Agents Chemother. 2014 Jul;58(7):3689-96. doi: 10.1128/AAC.02798-13. Epub 2014 Apr 21. Antimicrob Agents Chemother. 2014. PMID: 24752266 Free PMC article.
Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.
Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE. Kakkola L, et al. Among authors: denisova ov. Cell Death Dis. 2013 Jul 25;4(7):e742. doi: 10.1038/cddis.2013.267. Cell Death Dis. 2013. PMID: 23887633 Free PMC article.
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.
Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T, Kuivanen S, Vapalahti O, Kantele A, Tynell J, Julkunen I, Kallio-Kokko H, Paavilainen H, Hukkanen V, Elliott RM, De Brabander JK, Saelens X, Kainov DE. Denisova OV, et al. J Biol Chem. 2012 Oct 12;287(42):35324-35332. doi: 10.1074/jbc.M112.392142. Epub 2012 Aug 21. J Biol Chem. 2012. PMID: 22910914 Free PMC article.
14 results