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Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms.
Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison MS, Chris Le X, Klotz LO, El-Kadi AO. Anwar-Mohamed A, et al. Among authors: denison ms. Free Radic Biol Med. 2014 Feb;67:171-87. doi: 10.1016/j.freeradbiomed.2013.10.810. Epub 2013 Oct 24. Free Radic Biol Med. 2014. PMID: 24161444
Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.
Maayah ZH, Ghebeh H, Alhaider AA, El-Kadi AO, Soshilov AA, Denison MS, Ansari MA, Korashy HM. Maayah ZH, et al. Among authors: denison ms. Toxicol Appl Pharmacol. 2015 Apr 15;284(2):217-26. doi: 10.1016/j.taap.2015.02.007. Epub 2015 Feb 17. Toxicol Appl Pharmacol. 2015. PMID: 25697376
225 results