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Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.
Yan Z, Kim GY, Deng X, Friedman E. Yan Z, et al. Among authors: deng x. J Biol Chem. 2002 Mar 22;277(12):9870-9. doi: 10.1074/jbc.M107646200. Epub 2002 Jan 9. J Biol Chem. 2002. PMID: 11784716 Free article.
We recently demonstrated that colon carcinoma cells transfected with oncogenic cellular K-rasV12, but not oncogenic cellular H-rasV12, switched from TGFbeta1-insensitive to TGFbeta1-growth-stimulated and also became more invasive (Yan, Z., Deng, X., and Friedman, E. …
We recently demonstrated that colon carcinoma cells transfected with oncogenic cellular K-rasV12, but not oncogenic cellular H-rasV12, switc …
The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.
Deng X, Mercer SE, Shah S, Ewton DZ, Friedman E. Deng X, et al. J Biol Chem. 2004 May 21;279(21):22498-504. doi: 10.1074/jbc.M400479200. Epub 2004 Mar 9. J Biol Chem. 2004. PMID: 15010468 Free article.
Mitogen stimulation then causes cells to enter G(1), reduces Mirk levels (Deng, X., Ewton, D., Pawlikowski, B., Maimone, M., and Friedman, E. (2003) J. ...
Mitogen stimulation then causes cells to enter G(1), reduces Mirk levels (Deng, X., Ewton, D., Pawlikowski, B., Maimone, M., a …
Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.
Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E. Zou Y, et al. Among authors: deng x. J Biol Chem. 2004 Jun 25;279(26):27790-8. doi: 10.1074/jbc.M403042200. Epub 2004 Apr 9. J Biol Chem. 2004. PMID: 15075324 Free article.
Destabilization was confirmed by induction of a stable Mirk transfectant of Mv1Lu cells, which blocked cell migration (Zou, Y., Lim, S., Lee, K., Deng, X., and Friedman, E. (2003) J. Biol. Chem. 278, 49573-49581), and caused a decrease in the half-life of endogenous …
Destabilization was confirmed by induction of a stable Mirk transfectant of Mv1Lu cells, which blocked cell migration (Zou, Y., Lim, S., Lee …
Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation.
Deng X, Ewton DZ, Mercer SE, Friedman E. Deng X, et al. J Biol Chem. 2005 Feb 11;280(6):4894-905. doi: 10.1074/jbc.M411894200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15546868 Free article.
Depletion of endogenous Mirk from C2C12 myoblasts by RNA interference blocks skeletal muscle differentiation (Deng, X., Ewton, D., Pawlikowski, B., Maimone, M., and Friedman, E. (2003) J. ...
Depletion of endogenous Mirk from C2C12 myoblasts by RNA interference blocks skeletal muscle differentiation (Deng, X., Ewton, …
11,906 results
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