Deng H - Search Results

1

Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.

Sun X, Wu B, Chiang HC, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris BT, Blommaert E, Gomez A, Garcia RE, Zhou Y, Mitra P, Prevost M, Zhang D, Banik D, Isaacs C, Berry D, Lai C, Chaldekas K, Latham PS, Brantner CA, Popratiloff A, Jin VX, Zhang N, Hu Y, Pujana MA, Curiel TJ, An Z, Li R. Sun X, et al. Among authors: deng h. Nature. 2021 Nov;599(7886):673-678. doi: 10.1038/s41586-021-04057-2. Epub 2021 Nov 3. Nature. 2021. PMID: 34732895 Free PMC article.

2

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

Fan X, Brezski RJ, Fa M, Deng H, Oberholtzer A, Gonzalez A, Dubinsky WP, Strohl WR, Jordan RE, Zhang N, An Z. Fan X, et al. Among authors: deng h. Breast Cancer Res. 2012 Aug 8;14(4):R116. doi: 10.1186/bcr3240. Breast Cancer Res. 2012. PMID: 22873525 Free PMC article.

3

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways.

Choi BK, Cai X, Yuan B, Huang Z, Fan X, Deng H, Zhang N, An Z. Choi BK, et al. Among authors: deng h. Protein Cell. 2012 Oct;3(10):781-9. doi: 10.1007/s13238-012-2065-y. Epub 2012 Sep 15. Protein Cell. 2012. PMID: 22983903 Free PMC article.

4

ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells.

Choi BK, Fan X, Deng H, Zhang N, An Z. Choi BK, et al. Among authors: deng h. Cancer Med. 2012 Aug;1(1):28-38. doi: 10.1002/cam4.10. Epub 2012 Jul 15. Cancer Med. 2012. PMID: 23342251 Free PMC article.

5

Engagement of immune effector cells by trastuzumab induces HER2/ERBB2 downregulation in cancer cells through STAT1 activation.

Shi Y, Fan X, Meng W, Deng H, Zhang N, An Z. Shi Y, et al. Among authors: deng h. Breast Cancer Res. 2014 Apr 2;16(2):R33. doi: 10.1186/bcr3637. Breast Cancer Res. 2014. PMID: 24693969 Free PMC article.

6

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies.

Fan X, Brezski RJ, Deng H, Dhupkar PM, Shi Y, Gonzalez A, Zhang S, Rycyzyn M, Strohl WR, Jordan RE, Zhang N, An Z. Fan X, et al. Among authors: deng h. Mol Cancer Ther. 2015 Mar;14(3):681-91. doi: 10.1158/1535-7163.MCT-14-0715. Epub 2014 Dec 31. Mol Cancer Ther. 2015. PMID: 25552368

7

Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages.

Shi Y, Fan X, Deng H, Brezski RJ, Rycyzyn M, Jordan RE, Strohl WR, Zou Q, Zhang N, An Z. Shi Y, et al. Among authors: deng h. J Immunol. 2015 May 1;194(9):4379-86. doi: 10.4049/jimmunol.1402891. Epub 2015 Mar 20. J Immunol. 2015. PMID: 25795760

8

Efficient generation of monoclonal antibodies from single rhesus macaque antibody secreting cells.

Meng W, Li L, Xiong W, Fan X, Deng H, Bett AJ, Chen Z, Tang A, Cox KS, Joyce JG, Freed DC, Thoryk E, Fu TM, Casimiro DR, Zhang N, A Vora K, An Z. Meng W, et al. Among authors: deng h. MAbs. 2015;7(4):707-18. doi: 10.1080/19420862.2015.1051440. MAbs. 2015. PMID: 25996084 Free PMC article.

9

Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity.

Zhang N, Deng H, Fan X, Gonzalez A, Zhang S, Brezski RJ, Choi BK, Rycyzyn M, Strohl W, Jordan R, An Z. Zhang N, et al. Among authors: deng h. Clin Cancer Res. 2015 Dec 1;21(23):5380-90. doi: 10.1158/1078-0432.CCR-15-1057. Epub 2015 Jul 29. Clin Cancer Res. 2015. PMID: 26224871

10

Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.

Noh K, Mangala LS, Han HD, Zhang N, Pradeep S, Wu SY, Ma S, Mora E, Rupaimoole R, Jiang D, Wen Y, Shahzad MMK, Lyons Y, Cho M, Hu W, Nagaraja AS, Haemmerle M, Mak CSL, Chen X, Gharpure KM, Deng H, Xiong W, Kingsley CV, Liu J, Jennings N, Birrer MJ, Bouchard RR, Lopez-Berestein G, Coleman RL, An Z, Sood AK. Noh K, et al. Among authors: deng h. Cell Rep. 2017 Dec 5;21(10):2785-2795. doi: 10.1016/j.celrep.2017.11.020. Cell Rep. 2017. PMID: 29212026 Free PMC article.

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