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T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
Vos WG, van Os BW, den Toom M, Beckers L, van Roomen CPAA, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP. Vos WG, et al. Among authors: den toom m. Front Immunol. 2024 Mar 4;15:1297893. doi: 10.3389/fimmu.2024.1297893. eCollection 2024. Front Immunol. 2024. PMID: 38504977 Free PMC article.
Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis.
van Os BW, Kusters PJH, den Toom M, Beckers L, van Tiel CM, Vos WG, de Jong E, Kieser A, van Roomen C, Binder CJ, Reiche ME, de Winther MP, Bosmans LA, Lutgens E. van Os BW, et al. Among authors: den toom m. Front Cardiovasc Med. 2023 May 5;10:1171764. doi: 10.3389/fcvm.2023.1171764. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37215541 Free PMC article.
Hyperlipidaemia elicits an atypical, T helper 1-like CD4+ T-cell response: a key role for very low-density lipoprotein.
van Os BW, Vos WG, Bosmans LA, van Tiel CM, Lith SC, den Toom MS, Beckers L, Levels JHM, van Wouw SAE, Zelcer N, Zaal EA, Berkers CR, van der Lest CHA, Helms JB, Weber C, Atzler D, de Winther MPJ, Baardman J, Lutgens E. van Os BW, et al. Among authors: den toom ms. Eur Heart J Open. 2023 Mar 3;3(2):oead013. doi: 10.1093/ehjopen/oead013. eCollection 2023 Mar. Eur Heart J Open. 2023. PMID: 36969380 Free PMC article.
Adipocytes control hematopoiesis and inflammation through CD40 signaling.
Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, Aarts SABM, Den Toom M, Beckers L, Weber C, Atzler D, Rensen PCN, Kooijman S, Lutgens E. Reiche ME, et al. Among authors: den toom m. Haematologica. 2023 Jul 1;108(7):1873-1885. doi: 10.3324/haematol.2022.281482. Haematologica. 2023. PMID: 36475519 Free PMC article.
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ. Willemsen L, et al. Among authors: den toom m. BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019. BMJ Open Diabetes Res Care. 2019. PMID: 31798899 Free PMC article.
23 results