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Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.
Benchekroun M, Ermolenko L, Tran MQ, Vagneux A, Nedev H, Delehouzé C, Souab M, Baratte B, Josselin B, Iorga BI, Ruchaud S, Bach S, Al-Mourabit A. Benchekroun M, et al. Among authors: delehouze c. Eur J Med Chem. 2020 Sep 1;201:112337. doi: 10.1016/j.ejmech.2020.112337. Epub 2020 Jun 25. Eur J Med Chem. 2020. PMID: 32659605
Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor.
Ahmadu AA, Delehouzé C, Haruna A, Mustapha L, Lawal BA, Udobre A, Baratte B, Triscornia C, Autret A, Robert T, Bulinski JC, Rousselot M, Simoes Eugénio M, Dimanche-Boitrel MT, Petzer JP, Legoabe LJ, Bach S. Ahmadu AA, et al. Among authors: delehouze c. Molecules. 2021 Jul 29;26(15):4599. doi: 10.3390/molecules26154599. Molecules. 2021. PMID: 34361750 Free PMC article.
Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis.
Le Cann F, Delehouzé C, Leverrier-Penna S, Filliol A, Comte A, Delalande O, Desban N, Baratte B, Gallais I, Piquet-Pellorce C, Faurez F, Bonnet M, Mettey Y, Goekjian P, Samson M, Vandenabeele P, Bach S, Dimanche-Boitrel MT. Le Cann F, et al. Among authors: delehouze c. FEBS J. 2017 Sep;284(18):3050-3068. doi: 10.1111/febs.14176. Epub 2017 Aug 11. FEBS J. 2017. PMID: 28715128 Free article.
6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury.
Delehouzé C, Leverrier-Penna S, Le Cann F, Comte A, Jacquard-Fevai M, Delalande O, Desban N, Baratte B, Gallais I, Faurez F, Bonnet MC, Hauteville M, Goekjian PG, Thuillier R, Favreau F, Vandenabeele P, Hauet T, Dimanche-Boitrel MT, Bach S. Delehouzé C, et al. Sci Rep. 2017 Oct 10;7(1):12931. doi: 10.1038/s41598-017-12788-4. Sci Rep. 2017. PMID: 29018243 Free PMC article.
Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.
Moine E, Dimier-Poisson I, Enguehard-Gueiffier C, Logé C, Pénichon M, Moiré N, Delehouzé C, Foll-Josselin B, Ruchaud S, Bach S, Gueiffier A, Debierre-Grockiego F, Denevault-Sabourin C. Moine E, et al. Among authors: delehouze c. Eur J Med Chem. 2015 Nov 13;105:80-105. doi: 10.1016/j.ejmech.2015.10.004. Epub 2015 Oct 9. Eur J Med Chem. 2015. PMID: 26479029
CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N, Oumata N, Galons H, Roumeliotis TI, Giannopoulou EG, Grenet J, Twitchell D, Lahti J, Mouchet N, Galibert MD, Garbis SD, Meijer L. Delehouzé C, et al. Oncogene. 2014 Dec 11;33(50):5675-87. doi: 10.1038/onc.2013.513. Epub 2013 Dec 9. Oncogene. 2014. PMID: 24317512 Free PMC article.
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