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MYC is sufficient to generate mid-life high-grade serous ovarian and uterine serous carcinomas in a p53-R270H mouse model.
Blackman A, Rees AC, Bowers RR, Jones CM, Vaena SG, Clark MA, Carter S, Villamor ED, Evans D, Emanuel AJ, Fullbright G, Long DT, Spruill L, Romeo MJ, Helke KL, Delaney JR. Blackman A, et al. Among authors: delaney jr. bioRxiv [Preprint]. 2024 Jan 29:2024.01.24.576924. doi: 10.1101/2024.01.24.576924. bioRxiv. 2024. PMID: 38352443 Free PMC article. Preprint.
Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.
Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, Stupack DG. Delaney JR, et al. PLoS Genet. 2020 Jan 10;16(1):e1008558. doi: 10.1371/journal.pgen.1008558. eCollection 2020 Jan. PLoS Genet. 2020. PMID: 31923184 Free PMC article.
Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis.
White-Gilbertson S, Lu P, Jones CM, Chiodini S, Hurley D, Das A, Delaney JR, Norris JS, Voelkel-Johnson C. White-Gilbertson S, et al. Among authors: delaney jr. Cancer Med. 2020 May;9(9):3142-3152. doi: 10.1002/cam4.2960. Epub 2020 Mar 5. Cancer Med. 2020. PMID: 32135040 Free PMC article.
115 results