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Engineered Cas9 extracellular vesicles as a novel gene editing tool.
Osteikoetxea X, Silva A, Lázaro-Ibáñez E, Salmond N, Shatnyeva O, Stein J, Schick J, Wren S, Lindgren J, Firth M, Madsen A, Mayr LM, Overman R, Davies R, Dekker N. Osteikoetxea X, et al. Among authors: dekker n. J Extracell Vesicles. 2022 May;11(5):e12225. doi: 10.1002/jev2.12225. J Extracell Vesicles. 2022. PMID: 35585651 Free PMC article.
Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery.
Ivanova A, Badertscher L, O'Driscoll G, Bergman J, Gordon E, Gunnarsson A, Johansson C, Munson MJ, Spinelli C, Torstensson S, Vilén L, Voirel A, Wiseman J, Rak J, Dekker N, Lázaro-Ibáñez E. Ivanova A, et al. Among authors: dekker n. Adv Sci (Weinh). 2023 Dec;10(34):e2304389. doi: 10.1002/advs.202304389. Epub 2023 Oct 22. Adv Sci (Weinh). 2023. PMID: 37867228 Free PMC article.
Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice.
Bartesaghi S, Wallenius K, Hovdal D, Liljeblad M, Wallin S, Dekker N, Barlind L, Davies N, Seeliger F, Winzell MS, Patel S, Theisen M, Brito L, Bergenhem N, Andersson S, Peng XR. Bartesaghi S, et al. Among authors: dekker n. Mol Ther Nucleic Acids. 2022 Apr 18;28:500-513. doi: 10.1016/j.omtn.2022.04.010. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35592498 Free PMC article.
Extracellular vesicles induce minimal hepatotoxicity and immunogenicity.
Saleh AF , Lázaro-Ibáñez E , Forsgard MA , Shatnyeva O , Osteikoetxea X , Karlsson F , Heath N , Ingelsten M , Rose J , Harris J , Mairesse M , Bates SM , Clausen M , Etal D , Leonard E , Fellows MD , Dekker N , Edmunds N . Saleh AF , et al. Among authors: dekker n. Nanoscale. 2019 Apr 4;11(14):6990-7001. doi: 10.1039/c8nr08720b. Nanoscale. 2019. PMID: 30916672
315 results