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Rational Design in Photopharmacology with Molecular Photoswitches.
Kobauri P, Dekker FJ, Szymanski W, Feringa BL. Kobauri P, et al. Among authors: dekker fj. Angew Chem Int Ed Engl. 2023 Jul 24;62(30):e202300681. doi: 10.1002/anie.202300681. Epub 2023 May 4. Angew Chem Int Ed Engl. 2023. PMID: 37026576 Review.
Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration.
Al-Dahmani ZM, Hadian M, Ruiz-Moreno AJ, Maria SA, Batista FA, Zhang R, Luo Y, Sadremomtaz A, van der Straat R, Spoor M, Dolga AM, Dekker FJ, S S AD, van Goor H, Groves MR. Al-Dahmani ZM, et al. Among authors: dekker fj. Protein Sci. 2023 Nov;32(11):e4794. doi: 10.1002/pro.4794. Protein Sci. 2023. PMID: 37800277 Free PMC article.
Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos.
Chen D, Osipyan A, Adriana J, Kader M, Gureev M, Knol CWJ, Sigmund MC, Xiao Z, van der Wouden PE, Cool RH, Poelarends GJ, Dekker FJ. Chen D, et al. Among authors: dekker fj. J Med Chem. 2023 Jul 13;66(13):8767-8781. doi: 10.1021/acs.jmedchem.3c00397. Epub 2023 Jun 23. J Med Chem. 2023. PMID: 37352470 Free PMC article.
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8.
Fiorentino F, Sementilli S, Menna M, Turrisi F, Tomassi S, Pellegrini FR, Iuzzolino A, D'Acunzo F, Feoli A, Wapenaar H, Taraglio S, Fraschetti C, Del Bufalo D, Sbardella G, Dekker FJ, Paiardini A, Trisciuoglio D, Mai A, Rotili D. Fiorentino F, et al. Among authors: dekker fj. J Med Chem. 2023 May 25;66(10):6591-6616. doi: 10.1021/acs.jmedchem.2c01937. Epub 2023 May 8. J Med Chem. 2023. PMID: 37155735 Free PMC article.
Discovery of highly potent HDAC8 PROTACs with anti-tumor activity.
Zhao C, Chen D, Suo F, Setroikromo R, Quax WJ, Dekker FJ. Zhao C, et al. Among authors: dekker fj. Bioorg Chem. 2023 Jul;136:106546. doi: 10.1016/j.bioorg.2023.106546. Epub 2023 Apr 17. Bioorg Chem. 2023. PMID: 37098288 Free article.
102 results