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Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
Darras FH, Pockes S, Huang G, Wehle S, Strasser A, Wittmann HJ, Nimczick M, Sotriffer CA, Decker M. Darras FH, et al. Among authors: decker m. ACS Chem Neurosci. 2014 Mar 19;5(3):225-42. doi: 10.1021/cn4002126. Epub 2014 Jan 14. ACS Chem Neurosci. 2014. PMID: 24422467 Free PMC article.
"Photo-Rimonabant": Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar "Cis-On" CB1R Antagonist.
Rodríguez-Soacha DA, Fender J, Ramírez YA, Collado JA, Muñoz E, Maitra R, Sotriffer C, Lorenz K, Decker M. Rodríguez-Soacha DA, et al. Among authors: decker m. ACS Chem Neurosci. 2021 May 5;12(9):1632-1647. doi: 10.1021/acschemneuro.1c00086. Epub 2021 Apr 15. ACS Chem Neurosci. 2021. PMID: 33856764 Free PMC article.
Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB1R) "Cis-On" Agonist.
Rodríguez-Soacha DA, Steinmüller SAM, Işbilir A, Fender J, Deventer MH, Ramírez YA, Tutov A, Sotriffer C, Stove CP, Lorenz K, Lohse MJ, Hislop JN, Decker M. Rodríguez-Soacha DA, et al. Among authors: decker m. ACS Chem Neurosci. 2022 Aug 17;13(16):2410-2435. doi: 10.1021/acschemneuro.2c00160. Epub 2022 Jul 26. ACS Chem Neurosci. 2022. PMID: 35881914
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model.
Spatz P, Steinmüller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M. Spatz P, et al. Among authors: decker m. J Med Chem. 2023 May 11;66(9):6414-6435. doi: 10.1021/acs.jmedchem.3c00541. Epub 2023 Apr 26. J Med Chem. 2023. PMID: 37127287 Free PMC article.
1,065 results