Decker M - Search Results

1

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model.

Spatz P, Steinmüller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M. Spatz P, et al. Among authors: decker m. J Med Chem. 2023 May 11;66(9):6414-6435. doi: 10.1021/acs.jmedchem.3c00541. Epub 2023 Apr 26. J Med Chem. 2023. PMID: 37127287 Free PMC article.

2

Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.

Hoefgen B, Decker M, Mohr P, Schramm AM, Rostom SA, El-Subbagh H, Schweikert PM, Rudolf DR, Kassack MU, Lehmann J. Hoefgen B, et al. Among authors: decker m. J Med Chem. 2006 Jan 26;49(2):760-9. doi: 10.1021/jm050846j. J Med Chem. 2006. PMID: 16420061

3

Multi-target compounds acting in the central nervous system designed from natural products.

Chen X, Decker M. Chen X, et al. Among authors: decker m. Curr Med Chem. 2013;20(13):1673-85. doi: 10.2174/0929867311320130007. Curr Med Chem. 2013. PMID: 23410166 Review.

4

Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.

Huang G, Kling B, Darras FH, Heilmann J, Decker M. Huang G, et al. Among authors: decker m. Eur J Med Chem. 2014 Jun 23;81:15-21. doi: 10.1016/j.ejmech.2014.05.002. Epub 2014 May 4. Eur J Med Chem. 2014. PMID: 24819955

5

Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.

Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M. Nimczick M, et al. Among authors: decker m. Bioorg Med Chem. 2014 Aug 1;22(15):3938-46. doi: 10.1016/j.bmc.2014.06.008. Epub 2014 Jun 13. Bioorg Med Chem. 2014. PMID: 24984935

6

Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.

Darras FH, Kling B, Sawatzky E, Heilmann J, Decker M. Darras FH, et al. Among authors: decker m. Bioorg Med Chem. 2014 Sep 1;22(17):5020-34. doi: 10.1016/j.bmc.2014.06.010. Epub 2014 Jun 26. Bioorg Med Chem. 2014. PMID: 25059502

7

Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.

Chen X, Klöckner J, Holze J, Zimmermann C, Seemann WK, Schrage R, Bock A, Mohr K, Tränkle C, Holzgrabe U, Decker M. Chen X, et al. Among authors: decker m. J Med Chem. 2015 Jan 22;58(2):560-76. doi: 10.1021/jm500860w. Epub 2014 Dec 19. J Med Chem. 2015. PMID: 25478907

8

Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.

Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M. Sawatzky E, et al. Among authors: decker m. J Med Chem. 2016 Mar 10;59(5):2067-82. doi: 10.1021/acs.jmedchem.5b01674. Epub 2016 Feb 17. J Med Chem. 2016. PMID: 26886849

9

Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.

Dolles D, Hoffmann M, Gunesch S, Marinelli O, Möller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M. Dolles D, et al. Among authors: decker m. J Med Chem. 2018 Feb 22;61(4):1646-1663. doi: 10.1021/acs.jmedchem.7b01760. Epub 2018 Feb 5. J Med Chem. 2018. PMID: 29400965

10

Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.

Rodríguez-Soacha DA, Scheiner M, Decker M. Rodríguez-Soacha DA, et al. Among authors: decker m. Eur J Med Chem. 2019 Oct 15;180:690-706. doi: 10.1016/j.ejmech.2019.07.040. Epub 2019 Jul 12. Eur J Med Chem. 2019. PMID: 31401465 Review.

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