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Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity".
Decara JM, Vázquez-Villa H, Brea J, Alonso M, Srivastava RK, Orio L, Alén F, Suárez J, Baixeras E, García-Cárceles J, Escobar-Peña A, Lutz B, Rodríguez R, Codesido E, Garcia-Ladona FJ, Bennett TA, Ballesteros JA, Cruces J, Loza MI, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML. Decara JM, et al. J Med Chem. 2022 Apr 14;65(7):5449-5461. doi: 10.1021/acs.jmedchem.1c01842. Epub 2022 Mar 29. J Med Chem. 2022. PMID: 35349261 Free PMC article.
Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats.
Alonso M, Serrano A, Vida M, Crespillo A, Hernandez-Folgado L, Jagerovic N, Goya P, Reyes-Cabello C, Perez-Valero V, Decara J, Macías-González M, Bermúdez-Silva FJ, Suárez J, Rodríguez de Fonseca F, Pavón FJ. Alonso M, et al. Br J Pharmacol. 2012 Apr;165(7):2274-91. doi: 10.1111/j.1476-5381.2011.01698.x. Br J Pharmacol. 2012. PMID: 21951309 Free PMC article.
Description of a bivalent cannabinoid ligand with hypophagic properties.
Fernández-Fernández C, Decara J, Bermúdez-Silva FJ, Sánchez E, Morales P, Gómez-Cañas M, Gómez-Ruíz M, Callado LF, Goya P, Rodríguez de Fonseca F, Martín MI, Fernández-Ruíz J, Meana JJ, Jagerovic N. Fernández-Fernández C, et al. Arch Pharm (Weinheim). 2013 Mar;346(3):171-9. doi: 10.1002/ardp.201200392. Epub 2013 Feb 1. Arch Pharm (Weinheim). 2013. PMID: 23371794
Discovery of Potent Dual PPARα Agonists/CB1 Ligands.
Pérez-Fernández R, Fresno N, Macías-González M, Elguero J, Decara J, Girón R, Rodríguez-Álvarez A, Martín MI, Rodríguez de Fonseca F, Goya P. Pérez-Fernández R, et al. ACS Med Chem Lett. 2011 Sep 16;2(11):793-7. doi: 10.1021/ml200091q. eCollection 2011 Nov 10. ACS Med Chem Lett. 2011. PMID: 24936232 Free PMC article.
115 results