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Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples.
Wu W, Ishamuddin SH, Quinn TW, Yerrum S, Zhang Y, Debaize LL, Kao PL, Duquette SM, Murakami MA, Mohseni M, Chow KH, Miettinen TP, Ligon KL, Manalis SR. Wu W, et al. Among authors: debaize ll. bioRxiv [Preprint]. 2024 Apr 28:2024.04.25.591092. doi: 10.1101/2024.04.25.591092. bioRxiv. 2024. PMID: 38712225 Free PMC article. Preprint.
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
Wu G, Yoshida N, Liu J, Zhang X, Xiong Y, Heavican-Foral TB, Mandato E, Liu H, Nelson GM, Yang L, Chen R, Donovan KA, Jones MK, Roshal M, Zhang Y, Xu R, Nirmal AJ, Jain S, Leahy C, Jones KL, Stevenson KE, Galasso N, Ganesan N, Chang T, Wu WC, Louissaint A, Debaize L, Yoon H, Dal Cin P, Chan WC, Ho Sui SJ, Ng SY, Feldman AL, Horwitz SM, Adelman K, Fischer ES, Chen CW, Weinstock DM, Brown M. Wu G, et al. Among authors: debaize l. Sci Transl Med. 2023 Sep 20;15(714):eadi7244. doi: 10.1126/scitranslmed.adi7244. Epub 2023 Sep 20. Sci Transl Med. 2023. PMID: 37729434 Free PMC article.
Hypoxia regulates CD9 expression and dissemination of B lymphoblasts.
Rouger-Gaudichon J, Cousin E, Jakobczyk H, Debaize L, Rio AG, Forestier A, Arnaud MP, Villacreces A, Praloran V, Jacamo R, Galibert MD, Troadec MB, Gandemer V. Rouger-Gaudichon J, et al. Among authors: debaize l. Leuk Res. 2022 Dec;123:106964. doi: 10.1016/j.leukres.2022.106964. Epub 2022 Sep 28. Leuk Res. 2022. PMID: 36335655 Free article.
ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.
Jakobczyk H, Jiang Y, Debaize L, Soubise B, Avner S, Sérandour AA, Rouger-Gaudichon J, Rio AG, Carroll JS, Raslova H, Gilot D, Liu Z, Demengeot J, Salbert G, Douet-Guilbert N, Corcos L, Galibert MD, Gandemer V, Troadec MB. Jakobczyk H, et al. Among authors: debaize l. Leukemia. 2022 Feb;36(2):549-554. doi: 10.1038/s41375-021-01409-9. Epub 2021 Sep 17. Leukemia. 2022. PMID: 34535762 Free PMC article.
Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia.
Jakobczyk H, Debaize L, Soubise B, Avner S, Rouger-Gaudichon J, Commet S, Jiang Y, Sérandour AA, Rio AG, Carroll JS, Wichmann C, Lie-A-Ling M, Lacaud G, Corcos L, Salbert G, Galibert MD, Gandemer V, Troadec MB. Jakobczyk H, et al. Among authors: debaize l. J Hematol Oncol. 2021 Mar 20;14(1):47. doi: 10.1186/s13045-021-01051-z. J Hematol Oncol. 2021. PMID: 33743795 Free PMC article.
Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair.
Layer JV, Debaize L, Van Scoyk A, House NC, Brown AJ, Liu Y, Stevenson KE, Hemann M, Roberts SA, Price BD, Weinstock DM, Day TA. Layer JV, et al. Among authors: debaize l. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27566-27577. doi: 10.1073/pnas.2014176117. Epub 2020 Oct 19. Proc Natl Acad Sci U S A. 2020. PMID: 33077594 Free PMC article.
Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.
Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB. Debaize L, et al. Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. Nucleic Acids Res. 2018. PMID: 30500954 Free PMC article.