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Page 1
Telomere dysfunction alters intestinal stem cell dynamics to promote cancer.
LaBella KA, Hsu WH, Li J, Qi Y, Liu Y, Liu J, Wu CC, Liu Y, Song Z, Lin Y, Blecher JM, Jiang S, Shang X, Han J, Spring DJ, Zhang J, Xia Y, DePinho RA. LaBella KA, et al. Among authors: depinho ra. Dev Cell. 2024 Mar 28:S1534-5807(24)00188-6. doi: 10.1016/j.devcel.2024.03.020. Online ahead of print. Dev Cell. 2024. PMID: 38574731
KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer.
Wei Y, Liu M, Yen EY, Yao J, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Theady MS, Park J, Cai Y, Takeda M, Vasquez M, Zhou Y, Zhao H, Viale A, Wang H, Zhao D, DePinho RA, Yao W, Ying H. Wei Y, et al. Among authors: depinho ra. bioRxiv [Preprint]. 2023 Sep 23:2023.09.21.558891. doi: 10.1101/2023.09.21.558891. bioRxiv. 2023. PMID: 37790498 Free PMC article. Preprint.
Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer.
Han J, Xu J, Liu Y, Liang S, LaBella KA, Chakravarti D, Spring DJ, Xia Y, DePinho RA. Han J, et al. Among authors: depinho ra. Genes Dev. 2023 Sep 1;37(17-18):818-828. doi: 10.1101/gad.351037.123. Epub 2023 Sep 29. Genes Dev. 2023. PMID: 37775182 Free PMC article.
The Y of cancer sex differences.
Li J, DePinho RA. Li J, et al. Among authors: depinho ra. Clin Transl Med. 2023 Sep;13(9):e1402. doi: 10.1002/ctm2.1402. Clin Transl Med. 2023. PMID: 37679889 Free PMC article. No abstract available.
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells.
Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Mahadevan KK, et al. Among authors: depinho ra. Dev Cell. 2023 Sep 11;58(17):1562-1577.e8. doi: 10.1016/j.devcel.2023.07.025. Epub 2023 Aug 24. Dev Cell. 2023. PMID: 37625403
Histone demethylase KDM5D upregulation drives sex differences in colon cancer.
Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, LaBella KA, Wu CJ, Dunner K Jr, Hsu WH, Lee R, Khanduri I, Terranova C, Akdemir K, Chakravarti D, Shang X, Spring DJ, Wang YA, DePinho RA. Li J, et al. Among authors: depinho ra. Nature. 2023 Jul;619(7970):632-639. doi: 10.1038/s41586-023-06254-7. Epub 2023 Jun 21. Nature. 2023. PMID: 37344599 Free PMC article.
Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism.
Khadka S, Lin YH, Ackroyd J, Chen YA, Sheng Y, Qian W, Guo S, Chen Y, Behr E, Barekatain Y, Uddin N, Arthur K, Yan V, Hsu WH, Chang Q, Poral A, Tran T, Chaurasia S, Georgiou DK, Asara JM, Barthel FP, Millward SW, DePinho RA, Muller FL. Khadka S, et al. Among authors: depinho ra. bioRxiv [Preprint]. 2023 Oct 19:2023.05.07.539744. doi: 10.1101/2023.05.07.539744. bioRxiv. 2023. PMID: 37214825 Free PMC article. Preprint.
Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer.
Gulhati P, Schalck A, Jiang S, Shang X, Wu CJ, Hou P, Ruiz SH, Soto LS, Parra E, Ying H, Han J, Dey P, Li J, Deng P, Sei E, Maeda DY, Zebala JA, Spring DJ, Kim M, Wang H, Maitra A, Moore D, Clise-Dwyer K, Wang YA, Navin NE, DePinho RA. Gulhati P, et al. Among authors: depinho ra. Nat Cancer. 2023 Jan;4(1):62-80. doi: 10.1038/s43018-022-00500-z. Epub 2022 Dec 30. Nat Cancer. 2023. PMID: 36585453 Free PMC article.
437 results