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Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC-46).
De Ridder TR, Campbell JE, Burke-Schwarz C, Clegg D, Elliot EL, Geller S, Kozak W, Pittenger ST, Pruitt JB, Riehl J, White J, Wiest ML, Johannes CM, Morton J, Jones PD, Schmidt PF, Gordon V, Reddell P. De Ridder TR, et al. J Vet Intern Med. 2021 Jan;35(1):415-429. doi: 10.1111/jvim.15806. Epub 2020 Jun 16. J Vet Intern Med. 2021. PMID: 32542733 Free PMC article.
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds.
Powell LC, Cullen JK, Boyle GM, De Ridder T, Yap PY, Xue W, Pierce CJ, Pritchard MF, Menzies GE, Abdulkarim M, Adams JYM, Stokniene J, Francis LW, Gumbleton M, Johns J, Hill KE, Jones AV, Parsons PG, Reddell P, Thomas DW. Powell LC, et al. Sci Transl Med. 2022 Sep 14;14(662):eabn3758. doi: 10.1126/scitranslmed.abn3758. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103515