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Page 1
In vitro production of infectious Plasmodium falciparum sporozoites.
Eappen AG, Li T, Marquette M, Chakravarty S, Kc N, Zanghi G, Hoffman BU, Hettiarachchi H, Patil A, Abebe Y, Tran C, Yossef AA, McWilliams I, Morrison RD, Rathakrishnan A, Inbar E, Aly ASI, De La Vega P, Belmonte M, Sedegah M, Wai T, Campo JJ, King H, Kappe SHI, Li M, Billingsley PF, Sim BKL, Hoffman SL. Eappen AG, et al. Among authors: de la vega p. Nature. 2022 Dec;612(7940):534-539. doi: 10.1038/s41586-022-05466-7. Epub 2022 Dec 7. Nature. 2022. PMID: 36477528
Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host.
Mikolajczak SA, Silva-Rivera H, Peng X, Tarun AS, Camargo N, Jacobs-Lorena V, Daly TM, Bergman LW, de la Vega P, Williams J, Aly AS, Kappe SH. Mikolajczak SA, et al. Among authors: de la vega p. Mol Cell Biol. 2008 Oct;28(20):6196-207. doi: 10.1128/MCB.00553-08. Epub 2008 Aug 18. Mol Cell Biol. 2008. PMID: 18710954 Free PMC article.
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.
VanBuskirk KM, O'Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB Jr, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG Jr, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH. VanBuskirk KM, et al. Among authors: de la vega p. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13004-9. doi: 10.1073/pnas.0906387106. Epub 2009 Jul 22. Proc Natl Acad Sci U S A. 2009. PMID: 19625622 Free PMC article.
Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites.
Mikolajczak SA, Sacci JB Jr, De La Vega P, Camargo N, VanBuskirk K, Krzych U, Cao J, Jacobs-Lorena M, Cowman AF, Kappe SH. Mikolajczak SA, et al. Among authors: de la vega p. Cell Microbiol. 2011 Aug;13(8):1250-60. doi: 10.1111/j.1462-5822.2011.01617.x. Epub 2011 Jun 24. Cell Microbiol. 2011. PMID: 21569184 Free PMC article.
Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity.
Hickey BW, Lumsden JM, Reyes S, Sedegah M, Hollingdale MR, Freilich DA, Luke TC, Charoenvit Y, Goh LM, Berzins MP, Bebris L, Sacci JB Jr, De La Vega P, Wang R, Ganeshan H, Abot EN, Carucci DJ, Doolan DL, Brice GT, Kumar A, Aguiar J, Nutman TB, Leitman SF, Hoffman SL, Epstein JE, Richie TL. Hickey BW, et al. Among authors: de la vega p. Malar J. 2016 Jul 22;15(1):377. doi: 10.1186/s12936-016-1435-y. Malar J. 2016. PMID: 27448805 Free PMC article. Clinical Trial.
PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodies.
Chattopadhyay R, Rathore D, Fujioka H, Kumar S, de la Vega P, Haynes D, Moch K, Fryauff D, Wang R, Carucci DJ, Hoffman SL. Chattopadhyay R, et al. Among authors: de la vega p. J Biol Chem. 2003 Jul 11;278(28):25977-81. doi: 10.1074/jbc.M300865200. Epub 2003 Apr 25. J Biol Chem. 2003. PMID: 12716913 Free article.
Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA.
Richie TL, Charoenvit Y, Wang R, Epstein JE, Hedstrom RC, Kumar S, Luke TC, Freilich DA, Aguiar JC, Sacci JB Jr, Sedegah M, Nosek RA Jr, De La Vega P, Berzins MP, Majam VF, Abot EN, Ganeshan H, Richie NO, Banania JG, Baraceros MF, Geter TG, Mere R, Bebris L, Limbach K, Hickey BW, Lanar DE, Ng J, Shi M, Hobart PM, Norman JA, Soisson LA, Hollingdale MR, Rogers WO, Doolan DL, Hoffman SL. Richie TL, et al. Among authors: de la vega p. Hum Vaccin Immunother. 2012 Nov 1;8(11):1564-84. doi: 10.4161/hv.22129. Epub 2012 Nov 1. Hum Vaccin Immunother. 2012. PMID: 23151451 Free PMC article. Clinical Trial.
51 results