De Jonghe S - Search Results

1

The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach.

Mirza MU, Alanko I, Vanmeert M, Muzzarelli KM, Salo-Ahen OMH, Abdullah I, Kovari IA, Claes S, De Jonghe S, Schols D, Schinazi RF, Kovari LC, Trant JF, Ahmad S, Froeyen M. Mirza MU, et al. Among authors: de jonghe s. Eur J Pharm Sci. 2022 Aug 1;175:106220. doi: 10.1016/j.ejps.2022.106220. Epub 2022 May 23. Eur J Pharm Sci. 2022. PMID: 35618201 Free article.

2

Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.

Parchina A, Froeyen M, Margamuljana L, Rozenski J, De Jonghe S, Briers Y, Lavigne R, Herdewijn P, Lescrinier E. Parchina A, et al. Among authors: de jonghe s. ChemMedChem. 2013 Aug;8(8):1373-83. doi: 10.1002/cmdc.201300146. Epub 2013 Jul 8. ChemMedChem. 2013. PMID: 23836539

3

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.

Luo M, Groaz E, Andrei G, Snoeck R, Kalkeri R, Ptak RG, Hartman T, Buckheit RW Jr, Schols D, De Jonghe S, Herdewijn P. Luo M, et al. Among authors: de jonghe s. J Med Chem. 2017 Jul 27;60(14):6220-6238. doi: 10.1021/acs.jmedchem.7b00416. Epub 2017 Jul 6. J Med Chem. 2017. PMID: 28682067

4

Synthesis and Anti-HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives.

Luo M, Groaz E, De Jonghe S, Schols D, Herdewijn P. Luo M, et al. Among authors: de jonghe s. Chem Biodivers. 2019 Feb;16(2):e1800532. doi: 10.1002/cbdv.201800532. Epub 2019 Jan 23. Chem Biodivers. 2019. PMID: 30431702

5

Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X.

Modranka J, Li J, Parchina A, Vanmeert M, Dumbre S, Salman M, Myllykallio H, Becker HF, Vanhoutte R, Margamuljana L, Nguyen H, Abu El-Asrar R, Rozenski J, Herdewijn P, De Jonghe S, Lescrinier E. Modranka J, et al. Among authors: de jonghe s. ChemMedChem. 2019 Mar 22;14(6):645-662. doi: 10.1002/cmdc.201800739. Epub 2019 Feb 20. ChemMedChem. 2019. PMID: 30702807

6

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.

Martinez-Gualda B, Pu SY, Froeyen M, Herdewijn P, Einav S, De Jonghe S. Martinez-Gualda B, et al. Among authors: de jonghe s. Bioorg Med Chem. 2020 Jan 1;28(1):115188. doi: 10.1016/j.bmc.2019.115188. Epub 2019 Nov 11. Bioorg Med Chem. 2020. PMID: 31757682

7

Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach.

Mirza MU, Saadabadi A, Vanmeert M, Salo-Ahen OMH, Abdullah I, Claes S, De Jonghe S, Schols D, Ahmad S, Froeyen M. Mirza MU, et al. Among authors: de jonghe s. Eur J Pharm Sci. 2020 Dec 1;155:105537. doi: 10.1016/j.ejps.2020.105537. Epub 2020 Sep 2. Eur J Pharm Sci. 2020. PMID: 32890663 Free PMC article.

8

Palladium-catalyzed cross-coupling reactions on a bromo-naphthalene scaffold in the search for novel human CC chemokine receptor 8 (CCR8) antagonists.

Verhaegen Y, Liu L, Nguyen TT, Van Loy T, Voet ARD, Schols D, Dehaen W, De Jonghe S. Verhaegen Y, et al. Among authors: de jonghe s. Bioorg Chem. 2021 Feb;107:104560. doi: 10.1016/j.bioorg.2020.104560. Epub 2020 Dec 16. Bioorg Chem. 2021. PMID: 33383325

9

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.

Martinez-Gualda B, Saul S, Froeyen M, Schols D, Herdewijn P, Einav S, De Jonghe S. Martinez-Gualda B, et al. Among authors: de jonghe s. Eur J Med Chem. 2021 Mar 5;213:113158. doi: 10.1016/j.ejmech.2021.113158. Epub 2021 Jan 12. Eur J Med Chem. 2021. PMID: 33497888

10

Corrigendum to 'Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach' [European Journal of Pharmaceutical Sciences 155 (2020) 105537].

Mirza MU, Saadabadi A, Vanmeert M, Salo-Ahen OMH, Abdullah I, Claes S, De Jonghe S, Schols D, Ahmad S, Froeyen M. Mirza MU, et al. Among authors: de jonghe s. Eur J Pharm Sci. 2021 Jul 1;162:105827. doi: 10.1016/j.ejps.2021.105827. Epub 2021 Apr 1. Eur J Pharm Sci. 2021. PMID: 33814256 Free PMC article. No abstract available.

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