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Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
De Filippis V, Quarzago D, Vindigni A, Di Cera E, Fontana A. De Filippis V, et al. Biochemistry. 1998 Sep 29;37(39):13507-15. doi: 10.1021/bi980717n. Biochemistry. 1998. PMID: 9753436
In a previous study, we described the solid-phase synthesis of a Trp3 analogue of fragment 1-47 of hirudin HM2, which displayed approximately 5-fold higher thrombin inhibitory potency relative to that of the natural product [De Filippis, V., et al. (1995) Bio …
In a previous study, we described the solid-phase synthesis of a Trp3 analogue of fragment 1-47 of hirudin HM2, which displayed approximatel …
Enhanced protein thermostability by Ala-->Aib replacement.
De Filippis V, De Antoni F, Frigo M, Polverino de Laureto P, Fontana A. De Filippis V, et al. Among authors: de antoni f. Biochemistry. 1998 Feb 10;37(6):1686-96. doi: 10.1021/bi971937o. Biochemistry. 1998. PMID: 9484240
The Aib analogs of fragment 255-316 were prepared by a semisynthetic approach in which the natural fragment 255-316 was coupled to synthetic analogs of peptide 303-316 using V8-protease in 50% (v/v) aqueous glycerol [De Filippis, V., and Fontana …
The Aib analogs of fragment 255-316 were prepared by a semisynthetic approach in which the natural fragment 255-316 was coupled to synthetic …
Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor.
De Filippis V, Russo I, Vindigni A, Di Cera E, Salmaso S, Fontana A. De Filippis V, et al. Protein Sci. 1999 Oct;8(10):2213-7. doi: 10.1110/ps.8.10.2213. Protein Sci. 1999. PMID: 10548068 Free PMC article.
Thrombin inhibition data indicate that the effects of amino acid replacements are perfectly additive if compared to the singly substituted analogues (De Filippis V, Quarzago D, Vindigni A, Di Cera E, Fontana A, 1998, Biochemistry 37:13507-13515), yielding a m …
Thrombin inhibition data indicate that the effects of amino acid replacements are perfectly additive if compared to the singly substituted a …
209 results