De Clercq E - Search Results

1

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

Skerlj R, Bridger G, McEachern E, Harwig C, Smith C, Kaller A, Veale D, Yee H, Skupinska K, Wauthy R, Wang L, Baird I, Zhu Y, Burrage K, Yang W, Sartori M, Huskens D, De Clercq E, Schols D. Skerlj R, et al. Among authors: de clercq e. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1414-8. doi: 10.1016/j.bmcl.2011.01.021. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21295470

2

A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.

Naif HM, Cunningham AL, Alali M, Li S, Nasr N, Buhler MM, Schols D, de Clercq E, Stewart G. Naif HM, et al. Among authors: de clercq e. J Virol. 2002 Apr;76(7):3114-24. doi: 10.1128/jvi.76.7.3114-3124.2002. J Virol. 2002. PMID: 11884536 Free PMC article.

3

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

Hatse S, Princen K, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: de clercq e. FEBS Lett. 2002 Sep 11;527(1-3):255-62. doi: 10.1016/s0014-5793(02)03143-5. FEBS Lett. 2002. PMID: 12220670 Free article.

4

Polysulfonates derived from metal thiolate complexes as inhibitors of HIV-1 and various other enveloped viruses in vitro.

Bergstrom DE, Lin X, Wood TD, Witvrouw M, Ikeda S, Andrei G, Snoeck R, Schols D, De Clercq E. Bergstrom DE, et al. Among authors: de clercq e. Antivir Chem Chemother. 2002 May;13(3):185-95. doi: 10.1177/095632020201300305. Antivir Chem Chemother. 2002. PMID: 12448691 Free article.

5

The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor.

Vermeire K, Bell TW, Choi HJ, Jin Q, Samala MF, Sodoma A, De Clercq E, Schols D. Vermeire K, et al. Among authors: de clercq e. Mol Pharmacol. 2003 Jan;63(1):203-10. doi: 10.1124/mol.63.1.203. Mol Pharmacol. 2003. PMID: 12488553

6

Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry.

Princen K, Hatse S, Vermeire K, De Clercq E, Schols D. Princen K, et al. Among authors: de clercq e. Cytometry A. 2003 Jan;51(1):35-45. doi: 10.1002/cyto.a.10008. Cytometry A. 2003. PMID: 12500303 Free article.

7

Reduced fitness of HIV-1 resistant to CXCR4 antagonists.

Armand-Ugón M, Quiñones-Mateu ME, Gutiérez A, Barretina J, Blanco J, Schols D, De Clercq E, Clotet B, Esté JA. Armand-Ugón M, et al. Among authors: de clercq e. Antivir Ther. 2003 Feb;8(1):1-8. Antivir Ther. 2003. PMID: 12713058

8

In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.

Jekle A, Keppler OT, De Clercq E, Schols D, Weinstein M, Goldsmith MA. Jekle A, et al. Among authors: de clercq e. J Virol. 2003 May;77(10):5846-54. doi: 10.1128/jvi.77.10.5846-5854.2003. J Virol. 2003. PMID: 12719578 Free PMC article.

9

Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells.

Willey SJ, Reeves JD, Hudson R, Miyake K, Dejucq N, Schols D, De Clercq E, Bell J, McKnight A, Clapham PR. Willey SJ, et al. Among authors: de clercq e. J Virol. 2003 Jun;77(11):6138-52. doi: 10.1128/jvi.77.11.6138-6152.2003. J Virol. 2003. PMID: 12743271 Free PMC article.

10

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.

Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: de clercq e. FEBS Lett. 2003 Jul 10;546(2-3):300-6. doi: 10.1016/s0014-5793(03)00609-4. FEBS Lett. 2003. PMID: 12832058 Free article.

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