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Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways.
Barravecchia I, De Cesari C, Forcato M, Scebba F, Pyankova OV, Bridger JM, Foster HA, Signore G, Borghini A, Andreassi M, Andreazzoli M, Bicciato S, Pè ME, Angeloni D. Barravecchia I, et al. Among authors: de cesari c. Cell Mol Life Sci. 2021 Dec 22;79(1):28. doi: 10.1007/s00018-021-04025-z. Cell Mol Life Sci. 2021. PMID: 34936031 Free PMC article.
Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells.
Barravecchia I, De Cesari C, Guadagni V, Signore G, Bertolini E, Giannelli SG, Scebba F, Martini D, Pè ME, Broccoli V, Andreazzoli M, Angeloni D, Demontis GC. Barravecchia I, et al. Among authors: de cesari c. Sci Rep. 2023 Apr 13;13(1):6025. doi: 10.1038/s41598-023-32571-y. Sci Rep. 2023. PMID: 37055439 Free PMC article.
Enriching the Arsenal of Pharmacological Tools against MICAL2.
Barravecchia I, Barresi E, Russo C, Scebba F, De Cesari C, Mignucci V, De Luca D, Salerno S, La Pietra V, Giustiniano M, Pelliccia S, Brancaccio D, Donati G, Da Settimo F, Taliani S, Angeloni D, Marinelli L. Barravecchia I, et al. Among authors: de cesari c. Molecules. 2021 Dec 11;26(24):7519. doi: 10.3390/molecules26247519. Molecules. 2021. PMID: 34946600 Free PMC article.
MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
Barravecchia I, Mariotti S, Pucci A, Scebba F, De Cesari C, Bicciato S, Tagliafico E, Tenedini E, Vindigni C, Cecchini M, Berti G, Vitiello M, Poliseno L, Mazzanti CM, Angeloni D. Barravecchia I, et al. Among authors: de cesari c. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2111-2124. doi: 10.1016/j.bbadis.2019.04.008. Epub 2019 Apr 18. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31004710 Free article.