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Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives.
de Castro S, Pérez-Pérez MJ, Lobatón E, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S. de Castro S, et al. Among authors: de clercq e. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):959-61. doi: 10.1081/NCN-120022695. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565321 No abstract available.
Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.
de Castro S, Lobatón E, Pérez-Pérez MJ, San-Félix A, Cordeiro A, Andrei G, Snoeck R, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S. de Castro S, et al. Among authors: de clercq e. J Med Chem. 2005 Feb 24;48(4):1158-68. doi: 10.1021/jm040868q. J Med Chem. 2005. PMID: 15715482
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs.
Auwerx J, Van Nieuwenhove J, Rodríguez-Barrios F, de Castro S, Velázquez S, Ceccherini-Silberstein F, De Clercq E, Camarasa MJ, Perno CF, Gago F, Balzarini J. Auwerx J, et al. Among authors: de clercq e, de castro s. FEBS Lett. 2005 Apr 25;579(11):2294-300. doi: 10.1016/j.febslet.2005.02.077. FEBS Lett. 2005. PMID: 15848161 Free article.
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile.
de Castro S, García-Aparicio C, Van Laethem K, Gago F, Lobatón E, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S. de Castro S, et al. Among authors: de clercq e. Antiviral Res. 2006 Aug;71(1):15-23. doi: 10.1016/j.antiviral.2006.02.009. Epub 2006 Mar 29. Antiviral Res. 2006. PMID: 16616962
814 results