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Molecular mechanism of the wake-promoting agent TAK-925.
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM. Yin J, et al. Among authors: de brabander jk. Nat Commun. 2022 May 25;13(1):2902. doi: 10.1038/s41467-022-30601-3. Nat Commun. 2022. PMID: 35614071 Free PMC article.
Structural basis for itraconazole-mediated NPC1 inhibition.
Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X. Long T, et al. Among authors: de brabander jk. Nat Commun. 2020 Jan 9;11(1):152. doi: 10.1038/s41467-019-13917-5. Nat Commun. 2020. PMID: 31919352 Free PMC article.
TK216 targets microtubules in Ewing sarcoma cells.
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG. Povedano JM, et al. Among authors: de brabander jk. Cell Chem Biol. 2022 Aug 18;29(8):1325-1332.e4. doi: 10.1016/j.chembiol.2022.06.002. Epub 2022 Jul 7. Cell Chem Biol. 2022. PMID: 35803262 Free PMC article.
Reply to: The G protein preference of orexin receptors is currently an unresolved issue.
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM. Yin J, et al. Among authors: de brabander jk. Nat Commun. 2023 Jun 1;14(1):3163. doi: 10.1038/s41467-023-38765-2. Nat Commun. 2023. PMID: 37264001 Free PMC article. No abstract available.
Lessons and revelations from biomimetic syntheses.
Razzak M, De Brabander JK. Razzak M, et al. Among authors: de brabander jk. Nat Chem Biol. 2011 Nov 15;7(12):865-75. doi: 10.1038/nchembio.709. Nat Chem Biol. 2011. PMID: 22086288
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Shi Y, et al. Among authors: de brabander jk. Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6. Nature. 2019. PMID: 30842654 Free PMC article.
77 results