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Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
Claes F, Rudyak S, Laird AS, Louros N, Beerten J, Debulpaep M, Michiels E, van der Kant R, Van Durme J, De Baets G, Houben B, Ramakers M, Yuan K, Gwee SSL, Hernandez S, Broersen K, Oliveberg M, Moahamed B, Kirstein J, Robberecht W, Rousseau F, Schymkowitz J. Claes F, et al. Among authors: de baets g. Protein Eng Des Sel. 2019 Dec 31;32(10):443-457. doi: 10.1093/protein/gzaa008. Protein Eng Des Sel. 2019. PMID: 32399571
Solubis: a webserver to reduce protein aggregation through mutation.
Van Durme J, De Baets G, Van Der Kant R, Ramakers M, Ganesan A, Wilkinson H, Gallardo R, Rousseau F, Schymkowitz J. Van Durme J, et al. Among authors: de baets g. Protein Eng Des Sel. 2016 Aug;29(8):285-9. doi: 10.1093/protein/gzw019. Epub 2016 Jun 9. Protein Eng Des Sel. 2016. PMID: 27284085
Solubis: optimize your protein.
De Baets G, Van Durme J, van der Kant R, Schymkowitz J, Rousseau F. De Baets G, et al. Bioinformatics. 2015 Aug 1;31(15):2580-2. doi: 10.1093/bioinformatics/btv162. Epub 2015 Mar 19. Bioinformatics. 2015. PMID: 25792555
Structural hot spots for the solubility of globular proteins.
Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J. Ganesan A, et al. Among authors: de smet f, de baets g. Nat Commun. 2016 Feb 24;7:10816. doi: 10.1038/ncomms10816. Nat Commun. 2016. PMID: 26905391 Free PMC article.
Selectivity of aggregation-determining interactions.
Ganesan A, Debulpaep M, Wilkinson H, Van Durme J, De Baets G, Jonckheere W, Ramakers M, Ivarsson Y, Zimmermann P, Van Eldere J, Schymkowitz J, Rousseau F. Ganesan A, et al. Among authors: de baets g. J Mol Biol. 2015 Jan 30;427(2):236-47. doi: 10.1016/j.jmb.2014.09.027. Epub 2014 Nov 7. J Mol Biol. 2015. PMID: 25451783
Sequence-dependent internalization of aggregating peptides.
Couceiro JR, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, Roose K, Saelens X, Schymkowitz J, Rousseau F. Couceiro JR, et al. Among authors: de smet f, de baets g. J Biol Chem. 2015 Jan 2;290(1):242-58. doi: 10.1074/jbc.M114.586636. Epub 2014 Nov 12. J Biol Chem. 2015. PMID: 25391649 Free PMC article.
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.
Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovičić A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L. Boeynaems S, et al. Among authors: de baets g. Sci Rep. 2016 Feb 12;6:20877. doi: 10.1038/srep20877. Sci Rep. 2016. PMID: 26869068 Free PMC article.
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