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TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging.
Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. Davizon-Castillo P, et al. Blood. 2019 Aug 29;134(9):727-740. doi: 10.1182/blood.2019000200. Epub 2019 Jul 16. Blood. 2019. PMID: 31311815 Free PMC article.
The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.
Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Shelton Earp H 3rd, DeRyckere D, Brass LF, Graham DK, Di Paola JA. Branchford BR, et al. J Thromb Haemost. 2018 Feb;16(2):352-363. doi: 10.1111/jth.13875. Epub 2018 Jan 12. J Thromb Haemost. 2018. PMID: 29045015 Free PMC article.
Platelet activation contributes to hypoxia-induced inflammation.
Delaney C, Davizon-Castillo P, Allawzi A, Posey J, Gandjeva A, Neeves K, Tuder RM, Di Paola J, Stenmark KR, Nozik ES. Delaney C, et al. Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L413-L421. doi: 10.1152/ajplung.00519.2020. Epub 2020 Dec 2. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33264579 Free PMC article.
Intense light as anticoagulant therapy in humans.
Oyama Y, Shuff S, Davizon-Castillo P, Clendenen N, Eckle T. Oyama Y, et al. Among authors: davizon castillo p. PLoS One. 2020 Dec 31;15(12):e0244792. doi: 10.1371/journal.pone.0244792. eCollection 2020. PLoS One. 2020. PMID: 33382840 Free PMC article.
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.
Chavez JS, Rabe JL, Loeffler D, Higa KC, Hernandez G, Mills TS, Ahmed N, Gessner RL, Ke Z, Idler BM, Niño KE, Kim H, Myers JR, Stevens BM, Davizon-Castillo P, Jordan CT, Nakajima H, Ashton J, Welner RS, Schroeder T, DeGregori J, Pietras EM. Chavez JS, et al. Among authors: davizon castillo p. J Exp Med. 2021 Jun 7;218(6):e20201169. doi: 10.1084/jem.20201169. J Exp Med. 2021. PMID: 33857288 Free PMC article.
21 results