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201 results

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Page 1
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy.
Giuffrida L, Sek K, Henderson MA, Lai J, Chen AXY, Meyran D, Todd KL, Petley EV, Mardiana S, Mølck C, Stewart GD, Solomon BJ, Parish IA, Neeson PJ, Harrison SJ, Kats LM, House IG, Darcy PK, Beavis PA. Giuffrida L, et al. Among authors: darcy pk. Nat Commun. 2021 May 28;12(1):3236. doi: 10.1038/s41467-021-23331-5. Nat Commun. 2021. PMID: 34050151 Free PMC article.
Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice.
Westwood JA, Murray WK, Trivett M, Shin A, Neeson P, MacGregor DP, Haynes NM, Trapani JA, Mayura-Guru P, Fox S, Peinert S, Honemann D, Prince HM, Ritchie D, Scott AM, Smyth FE, Smyth MJ, Darcy PK, Kershaw MH. Westwood JA, et al. Among authors: darcy pk. Gene Ther. 2008 Jul;15(14):1056-66. doi: 10.1038/gt.2008.47. Epub 2008 Mar 27. Gene Ther. 2008. PMID: 18369322
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.
Westwood JA, Murray WK, Trivett M, Haynes NM, Solomon B, Mileshkin L, Ball D, Michael M, Burman A, Mayura-Guru P, Trapani JA, Peinert S, Hönemann D, Miles Prince H, Scott AM, Smyth MJ, Darcy PK, Kershaw MH. Westwood JA, et al. Among authors: darcy pk. J Immunother. 2009 Apr;32(3):292-301. doi: 10.1097/CJI.0b013e31819b7c8e. J Immunother. 2009. PMID: 19242371
Tumor ablation by gene-modified T cells in the absence of autoimmunity.
Wang LX, Westwood JA, Moeller M, Duong CP, Wei WZ, Malaterre J, Trapani JA, Neeson P, Smyth MJ, Kershaw MH, Darcy PK. Wang LX, et al. Among authors: darcy pk. Cancer Res. 2010 Dec 1;70(23):9591-8. doi: 10.1158/0008-5472.CAN-10-2884. Epub 2010 Nov 23. Cancer Res. 2010. PMID: 21098715
CD73-deficient mice are resistant to carcinogenesis.
Stagg J, Beavis PA, Divisekera U, Liu MC, Möller A, Darcy PK, Smyth MJ. Stagg J, et al. Among authors: darcy pk. Cancer Res. 2012 May 1;72(9):2190-6. doi: 10.1158/0008-5472.CAN-12-0420. Epub 2012 Mar 6. Cancer Res. 2012. PMID: 22396496
CD73: a potent suppressor of antitumor immune responses.
Beavis PA, Stagg J, Darcy PK, Smyth MJ. Beavis PA, et al. Among authors: darcy pk. Trends Immunol. 2012 May;33(5):231-7. doi: 10.1016/j.it.2012.02.009. Epub 2012 Apr 7. Trends Immunol. 2012. PMID: 22487321 Review.
201 results