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Page 1
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Postel S, Wissler L, Johansson CA, Gunnarsson A, Gordon E, Collins B, Castaldo M, Köhler C, Öling D, Johansson P, Fröderberg Roth L, Beinsteiner B, Dainty I, Delaney S, Klaholz BP, Billas IML, Edman K. Postel S, et al. Among authors: dainty i. Nat Struct Mol Biol. 2023 Mar;30(3):286-295. doi: 10.1038/s41594-022-00914-4. Epub 2023 Feb 6. Nat Struct Mol Biol. 2023. PMID: 36747092
AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.
van Laar JM, Lei A, Safy-Khan M, Almquist J, Belfield G, Edman K, Öberg L, Angermann BR, Dillmann I, Berntsson P, Etal D, Dainty I, Astbury C, Belvisi MG, Nemes S, Platt A, Prothon S, Samuelsson S, Svanberg P, Keen C; SEMRA study group. van Laar JM, et al. Among authors: dainty i. Clin Transl Sci. 2023 Dec;16(12):2494-2506. doi: 10.1111/cts.13624. Epub 2023 Oct 23. Clin Transl Sci. 2023. PMID: 37873558 Free PMC article. Clinical Trial.
Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle.
Koziol-White C, Johnstone TB, Corpuz ML, Cao G, Orfanos S, Parikh V, Deeney B, Tliba O, Ostrom RS, Dainty I, Panettieri RA Jr. Koziol-White C, et al. Among authors: dainty i. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L345-L355. doi: 10.1152/ajplung.00393.2019. Epub 2019 Nov 20. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31747297 Free PMC article.
From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.
Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, Thorne P, Young A. Alcaraz L, et al. Among authors: dainty i. Bioorg Med Chem Lett. 2012 Jan 1;22(1):689-95. doi: 10.1016/j.bmcl.2011.10.049. Epub 2011 Oct 20. Bioorg Med Chem Lett. 2012. PMID: 22079756
Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure.
Düringer C, Grundström G, Gürcan E, Dainty IA, Lawson M, Korn SH, Jerre A, Håkansson HF, Wieslander E, Fredriksson K, Sköld CM, Löfdahl M, Löfdahl CG, Nicholls DJ, Silberstein DS. Düringer C, et al. Among authors: dainty ia. Br J Pharmacol. 2009 Sep;158(1):169-79. doi: 10.1111/j.1476-5381.2009.00262.x. Epub 2009 Jun 22. Br J Pharmacol. 2009. PMID: 19558544 Free PMC article.
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