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Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. Nation DA, et al. Nat Med. 2019 Feb;25(2):270-276. doi: 10.1038/s41591-018-0297-y. Epub 2019 Jan 14. Nat Med. 2019. PMID: 30643288 Free PMC article.
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. Montagne A, et al. Nature. 2020 May;581(7806):71-76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29. Nature. 2020. PMID: 32376954 Free PMC article.
Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast MRI study.
Pahlavian SH, Wang X, Ma S, Zheng H, Casey M, D'Orazio LM, Shao X, Ringman JM, Chui H, Wang DJ, Yan L. Pahlavian SH, et al. Among authors: d orazio lm. J Cereb Blood Flow Metab. 2021 Mar;41(3):670-683. doi: 10.1177/0271678X20927101. Epub 2020 Jun 5. J Cereb Blood Flow Metab. 2021. PMID: 32501154 Free PMC article.
Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial.
Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN, Schneider LS, Yassine HN. Arellanes IC, et al. Among authors: d orazio lm. EBioMedicine. 2020 Sep;59:102883. doi: 10.1016/j.ebiom.2020.102883. Epub 2020 Jul 17. EBioMedicine. 2020. PMID: 32690472 Free PMC article. Clinical Trial.
MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.
Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM; MarkVCID Consortium. Wilcock D, et al. Among authors: d orazio lm. Alzheimers Dement. 2021 Apr;17(4):704-715. doi: 10.1002/alz.12215. Epub 2021 Jan 21. Alzheimers Dement. 2021. PMID: 33480172 Free PMC article.
Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease.
Jann K, Shao X, Ma SJ, Cen SY, D'Orazio L, Barisano G, Yan L, Casey M, Lamas J, Staffaroni AM, Kramer JH, Ringman JM, Wang DJJ. Jann K, et al. Front Neurosci. 2021 Jan 27;15:627627. doi: 10.3389/fnins.2021.627627. eCollection 2021. Front Neurosci. 2021. PMID: 33584191 Free PMC article.
Characterization of spastic paraplegia in a family with a novel PSEN1 mutation.
Ringman JM, Dorrani N, Fernández SG, Signer R, Martinez-Agosto J, Lee H, Douine ED, Qiao Y, Shi Y, D'Orazio L, Pawar S, Robbie L, Kashani AH, Singer M, Byers JT, Magaki S, Guzman S, Sagare A, Zlokovic B, Cederbaum S, Nelson S, Sheikh-Bahaei N, Chui HC, Chávez-Gutiérrez L, Vinters HV. Ringman JM, et al. Brain Commun. 2023 Feb 15;5(2):fcad030. doi: 10.1093/braincomms/fcad030. eCollection 2023. Brain Commun. 2023. PMID: 36895955 Free PMC article.
24 results