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Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study.
Tassone P, Di Martino MT, Arbitrio M, Fiorillo L, Staropoli N, Ciliberto D, Cordua A, Scionti F, Bertucci B, Salvino A, Lopreiato M, Thunarf F, Cuomo O, Zito MC, De Fina MR, Brescia A, Gualtieri S, Riillo C, Manti F, Caracciolo D, Barbieri V, Di Paola ED, Di Francesco AE, Tagliaferri P. Tassone P, et al. Among authors: cuomo o. J Hematol Oncol. 2023 Jun 26;16(1):68. doi: 10.1186/s13045-023-01468-8. J Hematol Oncol. 2023. PMID: 37365583 Free PMC article. Clinical Trial.
miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review.
Di Martino MT, Arbitrio M, Caracciolo D, Cordua A, Cuomo O, Grillone K, Riillo C, Caridà G, Scionti F, Labanca C, Romeo C, Siciliano MA, D'Apolito M, Napoli C, Montesano M, Farenza V, Uppolo V, Tafuni M, Falcone F, D'Aquino G, Calandruccio ND, Luciano F, Pensabene L, Tagliaferri P, Tassone P. Di Martino MT, et al. Among authors: cuomo o. Mol Ther Nucleic Acids. 2022 Feb 11;27:1191-1224. doi: 10.1016/j.omtn.2022.02.005. eCollection 2022 Mar 8. Mol Ther Nucleic Acids. 2022. PMID: 35282417 Free PMC article. Review.
Autoimmune colitis and neutropenia in adjuvant anti-PD-1 therapy for malignant melanoma: efficacy of Vedolizumab, a case report.
d'Apolito M, Spagnuolo R, Siciliano MA, Barbieri V, Cosco C, Fiorillo L, Cuomo O, Zuccalà V, Correale P, Pensabene L, Rossi M, Doldo P, Tassone P, Tagliaferri P. d'Apolito M, et al. Among authors: cuomo o. Ther Adv Chronic Dis. 2022 Jan 13;13:20406223211063024. doi: 10.1177/20406223211063024. eCollection 2022. Ther Adv Chronic Dis. 2022. PMID: 35070249 Free PMC article.
Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex.
Guida N, Serani A, Sanguigno L, Mascolo L, Cuomo O, Fioriniello S, Marano D, Ragione FD, Anzilotti S, Brancaccio P, Molinaro P, Pignataro G, Annunziato L, Formisano L. Guida N, et al. Among authors: cuomo o. J Am Heart Assoc. 2024 Mar 19;13(6):e030460. doi: 10.1161/JAHA.123.030460. Epub 2024 Mar 8. J Am Heart Assoc. 2024. PMID: 38456444 Free PMC article.
Anti-miRNA103/107 encapsulated in transferrin-conjugated lipid nanoparticles crosses blood-brain barrier and reduces brain ischemic damage.
Cepparulo P, Cuomo O, Campani V, Vinciguerra A, Sisalli MJ, Nele V, Anzilotti S, Valsecchi V, Casamassa A, Brancaccio P, Scorziello A, De Rosa G, Annunziato L, Pignataro G. Cepparulo P, et al. Among authors: cuomo o. Mol Ther Nucleic Acids. 2024 Feb 2;35(1):102131. doi: 10.1016/j.omtn.2024.102131. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38379726 Free PMC article.
Postconditioning promotes recovery in the neurovascular unit after stroke.
Esposito E, Licastro E, Cuomo O, Lo EH, Hayakawa K, Pignataro G. Esposito E, et al. Among authors: cuomo o. Front Cell Neurosci. 2023 Sep 8;17:1260389. doi: 10.3389/fncel.2023.1260389. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37744881 Free PMC article.
miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia.
Cepparulo P, Brancaccio P, Sirabella R, Anzilotti S, Guida N, Laudati G, Valsecchi V, Vinciguerra A, Viscardi V, D'Esposito L, Formisano L, Annunziato L, Pignataro G, Cuomo O. Cepparulo P, et al. Among authors: cuomo o. CNS Neurosci Ther. 2024 Mar;30(3):e14448. doi: 10.1111/cns.14448. Epub 2023 Sep 18. CNS Neurosci Ther. 2024. PMID: 37718696 Free PMC article.
Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death.
Sanguigno L, Guida N, Anzilotti S, Cuomo O, Mascolo L, Serani A, Brancaccio P, Pennacchio G, Licastro E, Pignataro G, Molinaro P, Annunziato L, Formisano L. Sanguigno L, et al. Among authors: cuomo o. Int J Biol Sci. 2023 May 11;19(9):2695-2710. doi: 10.7150/ijbs.80735. eCollection 2023. Int J Biol Sci. 2023. PMID: 37324938 Free PMC article.
Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke.
Valente A, Mariani J, Seminara S, Tettamanti M, Pignataro G, Perego C, Sironi L, Pedata F, Amantea D, Bacigaluppi M, Vinciguerra A, Diamanti S, Viganò M, Santangelo F, Zoia CP, Rodriguez-Menendez V, Castiglioni L, Rzemieniec J, Dettori I, Bulli I, Coppi E, Di Santo C, Cuomo O, Gullotta GS, Butti E, Bagetta G, Martino G, De Simoni MG, Ferrarese C, Fumagalli S, Beretta S; TRICS study group. Valente A, et al. Among authors: cuomo o. J Cereb Blood Flow Metab. 2023 Jul;43(7):1077-1088. doi: 10.1177/0271678X231159958. Epub 2023 Feb 23. J Cereb Blood Flow Metab. 2023. PMID: 36823998 Free PMC article.
113 results