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Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats.
Barsante MM, Cunha TM, Allegretti M, Cattani F, Policani F, Bizzarri C, Tafuri WL, Poole S, Cunha FQ, Bertini R, Teixeira MM. Barsante MM, et al. Among authors: cunha tm, cunha fq. Br J Pharmacol. 2008 Mar;153(5):992-1002. doi: 10.1038/sj.bjp.0707462. Epub 2007 Sep 24. Br J Pharmacol. 2008. PMID: 17891165 Free PMC article.
Commensal microbiota is fundamental for the development of inflammatory pain.
Amaral FA, Sachs D, Costa VV, Fagundes CT, Cisalpino D, Cunha TM, Ferreira SH, Cunha FQ, Silva TA, Nicoli JR, Vieira LQ, Souza DG, Teixeira MM. Amaral FA, et al. Among authors: cunha tm, cunha fq. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2193-7. doi: 10.1073/pnas.0711891105. Epub 2008 Feb 11. Proc Natl Acad Sci U S A. 2008. PMID: 18268332 Free PMC article.
Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice.
Cunha TM, Barsante MM, Guerrero AT, Verri WA Jr, Ferreira SH, Coelho FM, Bertini R, Di Giacinto C, Allegretti M, Cunha FQ, Teixeira MM. Cunha TM, et al. Among authors: cunha fq. Br J Pharmacol. 2008 May;154(2):460-70. doi: 10.1038/bjp.2008.94. Epub 2008 Mar 24. Br J Pharmacol. 2008. PMID: 18362895 Free PMC article.
A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5.
Vieira SM, Lemos HP, Grespan R, Napimoga MH, Dal-Secco D, Freitas A, Cunha TM, Verri WA Jr, Souza-Junior DA, Jamur MC, Fernandes KS, Oliver C, Silva JS, Teixeira MM, Cunha FQ. Vieira SM, et al. Among authors: cunha tm, cunha fq. Br J Pharmacol. 2009 Oct;158(3):779-89. doi: 10.1111/j.1476-5381.2009.00367.x. Epub 2009 Aug 20. Br J Pharmacol. 2009. PMID: 19702783 Free PMC article.
Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway.
Cunha TM, Roman-Campos D, Lotufo CM, Duarte HL, Souza GR, Verri WA Jr, Funez MI, Dias QM, Schivo IR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH. Cunha TM, et al. Among authors: cunha fq. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4442-7. doi: 10.1073/pnas.0914733107. Epub 2010 Feb 10. Proc Natl Acad Sci U S A. 2010. PMID: 20147620 Free PMC article.
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy.
Verri WA Jr, Souto FO, Vieira SM, Almeida SC, Fukada SY, Xu D, Alves-Filho JC, Cunha TM, Guerrero AT, Mattos-Guimaraes RB, Oliveira FR, Teixeira MM, Silva JS, McInnes IB, Ferreira SH, Louzada-Junior P, Liew FY, Cunha FQ. Verri WA Jr, et al. Among authors: cunha tm, cunha fq. Ann Rheum Dis. 2010 Sep;69(9):1697-703. doi: 10.1136/ard.2009.122655. Epub 2010 May 14. Ann Rheum Dis. 2010. PMID: 20472598
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
Amaral FA, Costa VV, Tavares LD, Sachs D, Coelho FM, Fagundes CT, Soriani FM, Silveira TN, Cunha LD, Zamboni DS, Quesniaux V, Peres RS, Cunha TM, Cunha FQ, Ryffel B, Souza DG, Teixeira MM. Amaral FA, et al. Among authors: cunha ld, cunha tm, cunha fq. Arthritis Rheum. 2012 Feb;64(2):474-84. doi: 10.1002/art.33355. Arthritis Rheum. 2012. PMID: 21952942 Free article.
415 results